" /> Alvelestat - CISMeF





Preferred Label : Alvelestat;

NCIt synonyms : 6-Methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-((5-(methylsulfonyl)pyridin-2-yl)methyl)-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamide;

NCIt definition : An orally bioavailable, selective and reversible inhibitor of human neutrophil elastase (NE), with potential anti-inflammatory activity. Upon administration, alvelestat binds to and inhibits the activity of human NE. This inhibits NE-mediated inflammatory responses, which may prevent lung inflammation and injury, and may improve lung function associated with NE-induced respiratory diseases. NE, a serine protease released by neutrophils during inflammation, is upregulated in a number of respiratory diseases.;

UNII : 6Y5629322X;

InChIKey : QNQZWEGMKJBHEM-UHFFFAOYSA-N;

CAS number : 848141-11-7;

Molecule name : AZD 9668; AZD-9668;

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04/05/2025


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