Preferred Label : Alvelestat;
NCIt synonyms : 6-Methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-((5-(methylsulfonyl)pyridin-2-yl)methyl)-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamide;
NCIt definition : An orally bioavailable, selective and reversible inhibitor of human neutrophil elastase
(NE), with potential anti-inflammatory activity. Upon administration, alvelestat binds
to and inhibits the activity of human NE. This inhibits NE-mediated inflammatory responses,
which may prevent lung inflammation and injury, and may improve lung function associated
with NE-induced respiratory diseases. NE, a serine protease released by neutrophils
during inflammation, is upregulated in a number of respiratory diseases.;
UNII : 6Y5629322X;
InChIKey : QNQZWEGMKJBHEM-UHFFFAOYSA-N;
CAS number : 848141-11-7;
Molecule name : AZD 9668; AZD-9668;
Origin ID : C125714;
UMLS CUI : C4085950;
Semantic type(s)
- concept_is_in_subset
- has_target
