TPM4/ALK Fusion Gene

Preferred Label : TPM4/ALK Fusion Gene;

NCIt synonyms : TPM4-ALK Fusion Gene; TPM4::ALK Fusion Gene;

NCIt definition : A fusion gene that results from a chromosomal translocation t(1;2)(q25;p23) which fuses most of the coding sequence of the TPM4 gene to the last 10 exons of the ALK gene. This rearrangement is associated with inflammatory myofibroblastic tumor.;

Details

Origin ID

C101085;

UMLS CUI

C3639984;

Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_encodes_gene_product
- TPM4/ALK Fusion Protein [NCIt concept]
gene_involved_in_molecular_abnormality
- TPM4-ALK Fusion Protein Expression [NCIt concept]
gene_involved_in_pathogenesis_of_disease
- Anaplastic Large Cell Lymphoma, ALK-Positive [NCIt concept]
- Inflammatory Myofibroblastic Tumor [NCIt concept]
gene_mapped_to_disease
- Abdominal Inflammatory Myofibroblastic Tumor [NCIt concept]
- Anaplastic Large Cell Lymphoma, ALK-Positive [NCIt concept]
- Bladder Inflammatory Myofibroblastic Tumor [NCIt concept]
- Breast Inflammatory Myofibroblastic Tumor [NCIt concept]
- Cardiac Inflammatory Myofibroblastic Tumor [NCIt concept]
- Central Nervous System Anaplastic Large Cell Lymphoma, ALK-Positive [NCIt concept]
- Central Nervous System Inflammatory Myofibroblastic Tumor [NCIt concept]
- Childhood Anaplastic Large Cell Lymphoma, ALK-Positive [NCIt concept]
- Childhood Inflammatory Myofibroblastic Tumor [NCIt concept]
- Digestive System Inflammatory Myofibroblastic Tumor [NCIt concept]
- Gastric Inflammatory Myofibroblastic Tumor [NCIt concept]
- Head and Neck Inflammatory Myofibroblastic Tumor [NCIt concept]
- Inflammatory Myofibroblastic Tumor [NCIt concept]
- Laryngeal Inflammatory Myofibroblastic Tumor [NCIt concept]
- Liver Inflammatory Myofibroblastic Tumor [NCIt concept]
- Lung Inflammatory Myofibroblastic Tumor [NCIt concept]
- Prostate Inflammatory Myofibroblastic Tumor [NCIt concept]
- Recurrent Systemic Anaplastic Large Cell Lymphoma, ALK-Positive [NCIt concept]
- Refractory Systemic Anaplastic Large Cell Lymphoma, ALK-Positive [NCIt concept]
- Retroperitoneal Inflammatory Myofibroblastic Tumor [NCIt concept]
- Systemic Anaplastic Large Cell Lymphoma, ALK-Positive [NCIt concept]
- Uterine Corpus Inflammatory Myofibroblastic Tumor [NCIt concept]
gene_plays_role_in_process
- Tyrosine Phosphorylation [NCIt concept]
related_to_genetic_biomarker
- ALK Gene [NCIt concept]
- TPM4 Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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