TPM4/ALK Fusion Protein

Preferred Label : TPM4/ALK Fusion Protein;

NCIt synonyms : TPM4-ALK Fusion Protein; Tropomyosin Alpha-4 Chain/ALK Tyrosine Kinase Receptor Fusion Protein; TPM4::ALK Fusion Protein;

NCIt definition : A fusion protein encoded by the TPM4/ALK fusion gene. This protein is comprised of most of the tropomyosin alpha-4 chain protein fused to the cytoplasmic domain of the ALK tyrosine kinase receptor protein.;

NCIt note : The TPM4/ALK fusion protein is a constitutively dimerized and activated tyrosine kinase.;

Details

Origin ID

C101086;

UMLS CUI

C3639985;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_encodes_gene_product
- Fusion Gene [NCIt concept]
- TPM4/ALK Fusion Gene [NCIt concept]
gene_product_plays_role_in_biological_process
- Tyrosine Phosphorylation [NCIt concept]
related_to_genetic_biomarker
- ALK Gene [NCIt concept]
- TPM4 Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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