TPM3/ALK Fusion Gene

Preferred Label : TPM3/ALK Fusion Gene;

NCIt synonyms : TPM3-ALK Fusion Gene; TPM3::ALK Fusion Gene;

NCIt definition : A fusion gene that results from a chromosomal translocation t(1;2)(q25;p23) which fuses most of the coding sequence of the TPM3 gene to the last 10 exons of the ALK gene. This rearrangement is associated with anaplastic large cell lymphoma and inflammatory myofibroblastic tumor.;

Details

Origin ID

C101083;

UMLS CUI

C3639982;

Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_encodes_gene_product
- TPM3/ALK Fusion Protein [NCIt concept]
gene_involved_in_molecular_abnormality
- TPM3-ALK Fusion Protein Expression [NCIt concept]
gene_involved_in_pathogenesis_of_disease
- Anaplastic Large Cell Lymphoma, ALK-Positive [NCIt concept]
- Inflammatory Myofibroblastic Tumor [NCIt concept]
gene_mapped_to_disease
- Abdominal Inflammatory Myofibroblastic Tumor [NCIt concept]
- Anaplastic Large Cell Lymphoma, ALK-Positive [NCIt concept]
- Bladder Inflammatory Myofibroblastic Tumor [NCIt concept]
- Breast Inflammatory Myofibroblastic Tumor [NCIt concept]
- Cardiac Inflammatory Myofibroblastic Tumor [NCIt concept]
- Central Nervous System Anaplastic Large Cell Lymphoma, ALK-Positive [NCIt concept]
- Central Nervous System Inflammatory Myofibroblastic Tumor [NCIt concept]
- Childhood Anaplastic Large Cell Lymphoma, ALK-Positive [NCIt concept]
- Childhood Inflammatory Myofibroblastic Tumor [NCIt concept]
- Digestive System Inflammatory Myofibroblastic Tumor [NCIt concept]
- Gastric Inflammatory Myofibroblastic Tumor [NCIt concept]
- Head and Neck Inflammatory Myofibroblastic Tumor [NCIt concept]
- Inflammatory Myofibroblastic Tumor [NCIt concept]
- Laryngeal Inflammatory Myofibroblastic Tumor [NCIt concept]
- Liver Inflammatory Myofibroblastic Tumor [NCIt concept]
- Lung Inflammatory Myofibroblastic Tumor [NCIt concept]
- Prostate Inflammatory Myofibroblastic Tumor [NCIt concept]
- Recurrent Systemic Anaplastic Large Cell Lymphoma, ALK-Positive [NCIt concept]
- Refractory Systemic Anaplastic Large Cell Lymphoma, ALK-Positive [NCIt concept]
- Retroperitoneal Inflammatory Myofibroblastic Tumor [NCIt concept]
- Systemic Anaplastic Large Cell Lymphoma, ALK-Positive [NCIt concept]
- Uterine Corpus Inflammatory Myofibroblastic Tumor [NCIt concept]
gene_plays_role_in_process
- Tyrosine Phosphorylation [NCIt concept]
related_to_genetic_biomarker
- ALK Gene [NCIt concept]
- TPM3 Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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