NF-kappa B kinase

Preferred Label : NF-kappa B kinase;

MeSH note : activates DNA-binding activity of NFkB by directly phosphorylating its p65 & p50 subunits; does not phosphorylate IkB; may have a central role in mediating various signals to NFkB; MW 43 kDa; amino acid sequence in second source; RefSeq NM_003954 (human), NM_016896 (mouse);

CISMeF synonym : EC 2.7.1.37 (Map3k14 protein, mouse); EC 2.7.1.37 (MAP3K14 protein, human); MAP3K14 protein, human; Map3k14 protein, mouse; Map4k4 protein, mouse;

MeSH synonym : nuclear factor kappa B kinase; Nik protein; NF-kappaB-inducing kinase; NFkB kinase;

MeSH hyponym : Nik protein, mouse; mitogen-activated protein kinase kinase kinase 14, mouse; NF- kappa beta-inducing kinase, human; NIK protein, human; mitogen-activated protein kinase kinase kinase 14, human; Map4k4 protein, rat;

Registry Number MeSH : EC 2.7.1.37; EC 2.7.11.25;

related registry number list (CISMeF) : EC 2.7.1.37;

Is substance : O;

UNII : EC 2.7.11.25;

Details

Origin ID

C084795;

UMLS CUI

C0249854;

Automatic exact mappings (from CISMeF team)
- 3-Phosphoinositide-Dependent Protein Kinase 1 [NCIt concept]
- Activin Receptor Type-1 [NCIt concept]
- Casein Kinase II Subunit Alpha [NCIt concept]
- Ceramide Transfer Protein [NCIt concept]
- Death-Associated Protein Kinase 1 [NCIt concept]
- Glycogen Synthase Kinase-3 Alpha [NCIt concept]
- LIM Domain Kinase 1 [NCIt concept]
- Mitogen-activated protein kinase kinase kinase 14 [OMIM gene]
- Serine/Threonine Protein Kinase [NCIt concept]
- Serine/Threonine-Protein Kinase Receptor R3 [NCIt concept]
MeSH indexing information
- nf-kappa b [MeSH Descriptor]
MeSH term(s) associated for indexing
- Protein Serine-Threonine Kinases [MeSH Descriptor]
Record concept(s)
- MAP3K14 protein, human [MeSH concept]
- Map3k14 protein, mouse [MeSH concept]
- Map4k4 protein, mouse [MeSH concept]
- NF-kappaB-Inducing Kinase [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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