Preferred Label : adagrasib;
MeSH synonym : 2-((S)-4-(7-(8-chloronaphthalen-1-yl)-2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-5,6,7,8-tetrahydropyrido(3,4-d)pyrimidin-4-yl)-1-(2-fluoroacryloyl)piperazin-2-yl)acetonitrile; 2-piperazineacetonitrile, 4-(7-(8-chloro-1-naphthalenyl)-5,6,7,8-tetrahydro-2-(((2S)-1-methyl-2-pyrrolidinyl)methoxy)pyrido(3,4-d)pyrimidin-4-yl)-1-(2-fluoro-1-oxo-2-propen-1-yl)-,
(2S)-;
MeSH hyponym : MRTX-849;
UNII : 8EOO6HQF8Y;
Origin ID : C000718190;
UMLS CUI : C5544276;
ATC code(s)
Currated CISMeF NLP mapping
MeSH term(s) associated for indexing
Pharmacological action(s)
Record concept(s)
Semantic type(s)
UMLS correspondences (same concept)
Validated automatic mappings to BTNT
https://www.has-sante.fr/jcms/p_3587072/fr/krazati-adagrasib-cancer-bronchique-non-a-petites-cellules
2025
false
false
false
France
adagrasib
KRAS NP_004976.2:p.G12C
KRAS Gene Mutation
evaluation of the transparency committee
adagrasib
carcinoma, non-small-cell lung
---
https://www.has-sante.fr/jcms/p_3597606/fr/krazati-adagrasib-cancer-bronchique-non-a-petites-cellules-avance-cbnpc
2025
false
false
false
France
bronchial neoplasms
treatment outcome
insurance, health, reimbursement
administration, oral
antineoplastic agents
adagrasib
adult
KRAS G12C Inhibitor
KRAS NP_004976.2:p.G12C
evaluation of the transparency committee
carcinoma, non-small-cell lung
adagrasib
---
https://ansm.sante.fr/tableau-acces-derogatoire/adagrasib
2025
false
false
false
France
French
administration, oral
drug information
antineoplastic agents
adagrasib
adagrasib
---
https://ansm.sante.fr/informations-de-securite/adagrasib-risque-potentiel-deffets-indesirables-cutanes-severes
2024
false
false
false
France
French
pharmacovigilance note
risk
adagrasib
stevens-johnson syndrome
epidermal necrolysis, toxic
adagrasib
antineoplastic agents
Adagrasib Regimen
---