Preferred Label : Adagrasib;
NCIt synonyms : KRAS G12C Inhibitor MRTX849;
NCIt definition : An orally available, small molecule inhibitor that targets the oncogenic KRAS substitution
mutation, G12C, with potential antineoplastic activity. Upon oral administration adagrasib
covalently binds to cytosine 12 within the switch II pocket of GDP-bound KRAS G12C,
thereby inhibiting mutant KRAS-dependent signaling. KRAS, a member of the RAS family
of oncogenes, serves an important role in cell signaling, division and differentiation.
Mutations of KRAS may induce constitutive signal transduction leading to tumor cell
growth, proliferation, invasion, and metastasis.;
UNII : 8EOO6HQF8Y;
CAS number : 2326521-71-3;
Drug name : Krazati;
Molecule name : MRTX 849; MRTX-849;
NCI Metathesaurus CUI : CL937069;
Codes from synonyms : 45753;
Origin ID : C157493;
UMLS CUI : C5544276;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- has_target
- is_component_of_chemotherapy_regimen
