grb2 adaptor protein

Preferred Label : grb2 adaptor protein;

MeSH definition : A signal transducing adaptor protein that links extracellular signals to the MAP KINASE SIGNALING SYSTEM. Grb2 associates with activated EPIDERMAL GROWTH FACTOR RECEPTOR and PLATELET-DERIVED GROWTH FACTOR RECEPTORS via its SH2 DOMAIN. It also binds to and translocates the SON OF SEVENLESS PROTEINS through its SH3 DOMAINS to activate PROTO-ONCOGENE PROTEIN P21(RAS).;

MeSH synonym : growth factor receptor bound protein 2; growth factor receptor-bound protein-2; abundant src homology protein;

MeSH hyponym : GRB2 adaptor protein, Grb3-3 isoform; GRB2 Adaptor Protein, Grb3 3 Isoform; Grb3-3 Adaptor Protein;

Is substance : O;

Details

Origin ID

D051380;

UMLS CUI

C0170953;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- GRAP Gene [NCIt concept]
- GRB2 wt Allele [NCIt concept]
- Growth Factor Receptor-Bound Protein 2 [NCIt concept]
- growth factor receptor bound protein 2 [HGNC gene]
Indexing information
- cyclo(CH2-CO-gamma-carboxylglutamyl-leucyl-(3'-aminotyrosyl)-Ac6c-asparaginyl-(5-aminovalyl)-cysteinyl(O))-amide [MeSH Supplementary Concept]
Record concept(s)
- GRB2 adaptor protein [MeSH concept]
- GRB2 adaptor protein, Grb3-3 isoform [MeSH concept]
Related MeSH Supplementary Concept(s)
- GAREM1 protein, human [MeSH Supplementary Concept]
- GAREM2 protein, human [MeSH Supplementary Concept]
- GRB2 protein, human [MeSH Supplementary Concept]
- Grb2 protein, mouse [MeSH Supplementary Concept]
- Grb2 protein, rat [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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