Preferred Label : kleine-levin syndrome;

MeSH definition : A rare condition characterized by recurrent hypersomnias associated with hyperphagia, occurring primarily in males in the second to third decade of life. Clinical features include mental confusion, excessive sleep requirements (approximately 18 hours per day), restlessness, and in some cases hallucinations. Episodes have a duration of days to weeks, and may recur several times per year. This condition may resolve spontaneously over several years. (From Adams, et al., Principles of Neurology, 6th ed, p569);

MeSH synonym : syndrome, kleine-levin-critchley; kleine-levin-critchley syndrome; syndrome, kleine-levin; hypersomnia, periodic; periodic hypersomnia; periodic hypersomnias; kleine levin critchley syndrome; Kleine-Levin hibernation syndrome; hibernation syndrome, Kleine-Levin; kleine levin hibernation syndrome; syndrome, Kleine-Levin hibernation; kleine levin syndrome;

CISMeF synonym : Kleine-Levin; KLS; kleine-levin's syndrome;

Related MeSH term : familial Kleine-Levin syndrome; Familial Kleine Levin Syndrome; Kleine-Levin Syndrome, Familial; Syndrome, Familial Kleine-Levin; Familial Hibernation (Kleine-Levin) Syndrome;

Wikipedia link : https://en.wikipedia.org/wiki/Kleine-levin syndrome;

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A rare condition characterized by recurrent hypersomnias associated with hyperphagia, occurring primarily in males in the second to third decade of life. Clinical features include mental confusion, excessive sleep requirements (approximately 18 hours per day), restlessness, and in some cases hallucinations. Episodes have a duration of days to weeks, and may recur several times per year. This condition may resolve spontaneously over several years. (From Adams, et al., Principles of Neurology, 6th ed, p569)

https://www.has-sante.fr/jcms/p_3292295/fr/syndrome-kleine-levin
2021
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risperidone
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http://www.kls-france.org/
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association of patients

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http://www.cochrane.org/fr/CD006685
2013
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french abstract

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http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=FR&Expert=33543
http://www.orpha.net/data/patho/Pro/fr/KleineLevin-FRfrPro10326.pdf
2008
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kleine-levin syndrome
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06/05/2025


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