complement factor h

Preferred Label : complement factor h;

MeSH definition : An important soluble regulator of the alternative pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It is a 139-kDa glycoprotein expressed by the liver and secreted into the blood. It binds to COMPLEMENT C3B and makes iC3b (inactivated complement 3b) susceptible to cleavage by COMPLEMENT FACTOR I. Complement factor H also inhibits the association of C3b with COMPLEMENT FACTOR B to form the C3bB proenzyme, and promotes the dissociation of Bb from the C3bBb complex (COMPLEMENT C3 CONVERTASE, ALTERNATIVE PATHWAY).;

MeSH synonym : factor h, complement; factor h;

MeSH CAS label : complement factor H;

MeSH Related Number : 103371-28-4 (mouse protein moiety reduced);

Registry Number MeSH : 80295-65-4;

Wikipedia link : https://en.wikipedia.org/wiki/Complement factor h;

Is substance : O;

Details

Origin ID

D017242;

UMLS CUI

C0056207;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Complement Factor H [NCIt concept]
- Complement factor [MedDRA Preferred Term]
- Complement factor (substance) [SNOMED CT concept]
- Complement factor H measurement (procedure) [SNOMED CT concept]
- Complement factor b [OMIM Phenotype]
- Complement factor h [OMIM gene]
- Complement factor increased [MedDRA Preferred Term]
- Factor [NCIt concept]
- Factor H deficiency (disorder) [SNOMED CT concept]
- Granzyme A [NCIt concept]
- Mathematical Factor [NCIt concept]
- blood-coagulation factor ii [Substance BNPC]
- blood-coagulation factor iii [Substance BNPC]
- blood-coagulation factor v [Substance BNPC]
- blood-coagulation factor x [Substance BNPC]
- complement factor H [HGNC gene]
- complement factor H [ORDO Gene]
- complement factor b, nos [SNOMED Notion]
- complement factor bb [SNOMED Notion]
- complement factor d [SNOMED Notion]
- f factor [SNOMED Notion]
- factor [IUPAC Term]
- fibrinogens [Substance BNPC]
- r factor [SNOMED Notion]
Indexing information
- CFHR3 protein, human [MeSH Supplementary Concept]
- bladder tumor-associated antigen [MeSH Supplementary Concept]
- cofactor-related protein 1, sand bass [MeSH Supplementary Concept]
- factor H-related protein 1 [MeSH Supplementary Concept]
- factor H-related protein 2 [MeSH Supplementary Concept]
Pharmacological action(s)
- complement inactivating agents [MeSH Descriptor]
Record concept(s)
- complement factor H [MeSH concept]
Related MeSH Supplementary Concept(s)
- CFH protein, human [MeSH Supplementary Concept]
- TT30 fusion protein, human [MeSH Supplementary Concept]
- adrenomedullin-binding protein 1, human [MeSH Supplementary Concept]
- adrenomedullin-binding protein 1, rat [MeSH Supplementary Concept]
- complement factor H deficiency [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- Complement factor H [LOINC component]
- Factor H (substance) [SNOMED CT concept]
- factor h [SNOMED Notion]

Keyword's position in hierarchy(ies) :

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