dystrophin - CISMeF

Preferred Label : dystrophin;

MeSH definition : A muscle protein localized in surface membranes which is the product of the Duchenne/Becker muscular dystrophy gene. Individuals with Duchenne muscular dystrophy usually lack dystrophin completely while those with Becker muscular dystrophy have dystrophin of an altered size. It shares features with other cytoskeletal proteins such as SPECTRIN and alpha-actinin but the precise function of dystrophin is not clear. One possible role might be to preserve the integrity and alignment of the plasma membrane to the myofibrils during muscle contraction and relaxation. MW 400 kDa.;

MeSH annotation : a muscle protein: see MeSH definition for relation to musc dystrophy; /biosyn /drug eff /physiol /ultrastruct permitted;

Wikipedia link : https://en.wikipedia.org/wiki/Dystrophin;

Is substance : O;

Détails

Origin ID

D016189;

UMLS CUI

C0079259;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Currated CISMeF NLP mapping
- Dystrophin [FMA entity]
- Dystrophin [NCIt concept]
Record concept(s)
- dystrophin [MeSH concept]
Related MeSH Supplementary Concept(s)
- 140-kDa dystrophin [MeSH Supplementary Concept]
- DMD protein, human [MeSH Supplementary Concept]
- Dmd protein, mouse [MeSH Supplementary Concept]
- Dp260 protein, mouse [MeSH Supplementary Concept]
- Dp260 protein, rat [MeSH Supplementary Concept]
- apo-dystrophin 1 [MeSH Supplementary Concept]
- dmd protein, rat [MeSH Supplementary Concept]
- dys-1 protein, C elegans [MeSH Supplementary Concept]
See also
- mice, inbred mdx [MeSH Descriptor]
- muscular dystrophy, duchenne [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Dystrophin [FMA entity]
- Dystrophin [NCIt concept]

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