thiorphan - CISMeF

Preferred Label : thiorphan;

MeSH definition : A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms.;

MeSH synonym : tiorphan; (3-Mercapto-2-benzylpropionyl)glycine;

MeSH hyponym : thiorphan, (S)-Isomer; thiorphan, (R)-Isomer;

MeSH CAS label : glycine, N-(2-(mercaptomethyl)-1-oxo-3-phenylpropyl)-, ( -)-;

MeSH Related Number : thiorphan, (R)-Isomer; thiorphan, (S)-Isomer; 107672-11-7 (cpd w/o isomeric designation); 76721-89-6 (Thiorphan); 95908-99-9; 95909-00-5;

Registry Number MeSH : 76721-89-6;

Related CAS MeSH : 95908-99-9 (Thiorphan, (R)-Isomer); 95909-00-5 (Thiorphan, (S)-Isomer);

Wikipedia link : https://en.wikipedia.org/wiki/Thiorphan;

Is substance : O;

UNII : B79L7B5X3Z;

InChIKey : LJJKNPQAGWVLDQ-UHFFFAOYSA-N;

Details

Origin ID

D015244;

UMLS CUI

C0039945;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analogs and derivatives [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- economics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
Pharmacological action(s)
- protease inhibitors [MeSH Descriptor]
Record concept(s)
- thiorphan [MeSH concept]
- thiorphan, (R)-Isomer [MeSH concept]
- thiorphan, (S)-Isomer [MeSH concept]
Related MeSH Supplementary Concept(s)
- ES 52 [MeSH Supplementary Concept]
- GB 52 [MeSH Supplementary Concept]
- S-acetylthiorphan [MeSH Supplementary Concept]
- azidothiorphan [MeSH Supplementary Concept]
- dexecadotril [MeSH Supplementary Concept]
- leucine thiorphan [MeSH Supplementary Concept]
- racecadotril [MeSH Supplementary Concept]
- retrothiorphan [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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