proline - CISMeF

Preferred Label : proline;

MeSH definition : A non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons.;

MeSH synonym : l proline; L-Proline;

MeSH CAS label : L-Proline;

MeSH Related Number : 147-85-3 (Proline);

Registry Number MeSH : 147-85-3;

MeSH annotation : /biosyn /defic /physiol permitted;

Wikipedia link : https://en.wikipedia.org/wiki/Proline;

Codes EINECS : 205-702-2;

Is substance : O;

medicament (CISMeF) : O;

UNII : 9DLQ4CIU6V;

InChIKey : ONIBWKKTOPOVIA-BYPYZUCNSA-N;

Details

Origin ID

D011392;

UMLS CUI

C0033382;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analogs and derivatives [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
CISMeF manual mappings
- proline [Substance BNPC]
Currated CISMeF NLP mapping
- Proline [NCIt concept]
- Proline [FMA entity]
- Proline [LOINC component]
- Proline (substance) [SNOMED CT concept]
- proline [SNOMED Notion]
- proline [Artificial nutrition thesaurus concept]
Indexing information
- PRRT2 protein, human [MeSH Supplementary Concept]
- Pro-Pro-Pro-NH2 [MeSH Supplementary Concept]
- PutP protein, E coli [MeSH Supplementary Concept]
- lacrimal proline rich 4 protein, human [MeSH Supplementary Concept]
- proline transport protein [MeSH Supplementary Concept]
- prolyl-4-hydroxyproline [MeSH Supplementary Concept]
- prolyl-proline [MeSH Supplementary Concept]
- prtb peptide [MeSH Supplementary Concept]
- xin protein, mouse [MeSH Supplementary Concept]
Record concept(s)
- proline [MeSH concept]
Related MeSH Supplementary Concept(s)
- (1S,3S)-3-amino-4-difluoromethylenecyclopentanecarboxylic acid [MeSH Supplementary Concept]
- (2,3)-3-hydroxy-3-methylproline [MeSH Supplementary Concept]
- (2S, 3R, 4R)-4-hydroxy-3-methylproline [MeSH Supplementary Concept]
- (2S,4R)-4-hydroxyproline(4-nitrobenzoate) [MeSH Supplementary Concept]
- (2S,4S)-perfluoro-tert-butyl 4-hydroxyproline [MeSH Supplementary Concept]
- (2S,5S)-trans-carboxymethylproline [MeSH Supplementary Concept]
- (S(a))-binam-D-prolinamide [MeSH Supplementary Concept]
- 1,4-diaminopyrrolidine-2,4-dicarboxylic acid [MeSH Supplementary Concept]
- 1-((5-(1-aminoethyl)-2-(8-methoxy-2-(triflurormethyl)-5-quinolinyl)-4-oxazolyl) carbonyl)-4-((cyclopropylcarbonyl)amino)proline ethyl ester [MeSH Supplementary Concept]
- 1-(2-(2-methyl-4-nitrophenyl)diaz-1-enyl)pyrrolidine-2-carboxylic acid [MeSH Supplementary Concept]
- 1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid [MeSH Supplementary Concept]
- 1-(5-((3,3-difluoropyrrolidin-1-yl)carbonyl)pyrrolidin-3-yl)-4-(4-fluoro-3-methylphenyl)-1H-1,2,3-triazole [MeSH Supplementary Concept]
- 1-(5-((3,3-difluoropyrrolidin-1-yl)carbonyl)pyrrolidin-3-yl)-4-(4-phenylphenyl)-1H-1,2,3-triazole [MeSH Supplementary Concept]
- 1-(5-chloro-1-((2,4-dimethoxyphenyl)sulfonyl)-3-(2-methoxyphenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl)-4-fluoro-N,N-dimethylprolinamide [MeSH Supplementary Concept]
- 1-aminoproline [MeSH Supplementary Concept]
- 1-carbamimidoylproline [MeSH Supplementary Concept]
- 2 nitroxyethyl ether LN-((2-(nitroxy)ethyl)fullerenyl)proline [MeSH Supplementary Concept]
- 2,4-methanoproline [MeSH Supplementary Concept]
- 2,5-di-(N-prolyl)-para-benzoquinone [MeSH Supplementary Concept]
- 2-((1-prolinamido)methyl)-6-(1-hydroxyethyl)penem-3-carboxylic acid [MeSH Supplementary Concept]
- 2-(4-pyridyl)thiazolidine-4-carboxylic acid [MeSH Supplementary Concept]
- 2-azido-N-(diphenylcarbamoyl)proline methyl ester [MeSH Supplementary Concept]
- 2-methylproline [MeSH Supplementary Concept]
- 2-methylselanazolidine-4-carboxylic acid [MeSH Supplementary Concept]
- 2-oxoselenazolidine-4-carboxylic acid [MeSH Supplementary Concept]
- 2-pyrrolecarboxylic acid [MeSH Supplementary Concept]
- 3,3-dimethyl isopropylidene proline [MeSH Supplementary Concept]
- 3,4-(aminomethano)proline [MeSH Supplementary Concept]
- 3,4-dehydroproline [MeSH Supplementary Concept]
- 3,4-dihydro-2H-pyrrole-5-carboxylic acid [MeSH Supplementary Concept]
- 3,5-methanoproline [MeSH Supplementary Concept]
- 3-((4-(2-styrylphenoxy)butanoyl)-4-hydroxyprolyl)thiazolidine [MeSH Supplementary Concept]
- 3-((prolyl)oxy)androst-16-eno(17,16-d)(1,2,3)thiadiazole [MeSH Supplementary Concept]
- 3-acetoxy-17-prolylaminoandrostane [MeSH Supplementary Concept]
- 3-allylproline [MeSH Supplementary Concept]
- 3-aza-9-hydroxyfluoren-9-ylcarbonyl-prolyl-2-aminomethyl-5-chlorobenzylamide [MeSH Supplementary Concept]
- 3-azidoproline [MeSH Supplementary Concept]
- 3-hydroxy-N-methylproline [MeSH Supplementary Concept]
- 3-mercaptoproline [MeSH Supplementary Concept]
- 3-methylproline [MeSH Supplementary Concept]
- 3-propylproline [MeSH Supplementary Concept]
- 3a,5,6,6a-tetrahydro-4H--pyrrolo(3,4-d)isoxazole-3,6-dicarboxylic acid [MeSH Supplementary Concept]
- 4,4'-diprolylamine [MeSH Supplementary Concept]
- 4,4-dicarboxy-5-(pyridoxyl-5'-phosphate)proline [MeSH Supplementary Concept]
- 4,4-dicarboxy-5-pyridoxylproline [MeSH Supplementary Concept]
- 4,4-difluoroproline [MeSH Supplementary Concept]
- 4,5-methanoproline [MeSH Supplementary Concept]
- 4-(beta-naphthalenyl)methoxyproline [MeSH Supplementary Concept]
- 4-N-prolyl-2-benzoquinone [MeSH Supplementary Concept]
- 4-aminopyrrolidine-2,4-dicarboxylic acid [MeSH Supplementary Concept]
- 4-aminopyrrolidine-2-carboxylic acid [MeSH Supplementary Concept]
- 4-azidoproline [MeSH Supplementary Concept]
- 4-carboxy-5-(pyridyloxy-5'-phosphate)proline [MeSH Supplementary Concept]
- 4-chloroproline [MeSH Supplementary Concept]
- 4-hydroxy-N-methylproline [MeSH Supplementary Concept]
- 4-ketoproline [MeSH Supplementary Concept]
- 4-mercaptoproline [MeSH Supplementary Concept]
- 4-methyleneproline [MeSH Supplementary Concept]
- 4-methylproline [MeSH Supplementary Concept]
- 4-n-propyl-L-proline [MeSH Supplementary Concept]
- 4-phenoxyproline [MeSH Supplementary Concept]
- 4-phenylbutanoyl-prolylcyanopyrrolidine [MeSH Supplementary Concept]
- 4-phosphorylproline [MeSH Supplementary Concept]
- 5-(1-(acetylamino)-2-methoxy-2-methylpentyl)-4-(1-propenyl)proline [MeSH Supplementary Concept]
- 5-(ethoxycarbonyl)methylproline [MeSH Supplementary Concept]
- 5-azido-N-(diphenylcarbamoyl)proline methyl ester [MeSH Supplementary Concept]
- 5-fluoro-methanoproline [MeSH Supplementary Concept]
- 5-hydroxymethanoproline [MeSH Supplementary Concept]
- 5-methyl-3-pyrrolidinecarboxylic acid [MeSH Supplementary Concept]
- 5-oxaproline [MeSH Supplementary Concept]
- 5-oxo-D-prolinepiperidinamide monohydrate [MeSH Supplementary Concept]
- 5-oxoprolinal [MeSH Supplementary Concept]
- 5-phenyl proline [MeSH Supplementary Concept]
- 5-tert-butylproline [MeSH Supplementary Concept]
- 5-trifluoromethylproline [MeSH Supplementary Concept]
- 6,6-dicarboxy-3,4-methano-L-proline [MeSH Supplementary Concept]
- 6-N-(2'-pyrrolidinylcarbonyl)amino-6-(2-methylpropyl)-8a-carboxamidoindolizidine-5-one [MeSH Supplementary Concept]
- 9-fluorenylmethoxycarbonyl-prolyl-pyrrolidine-2-nitrile [MeSH Supplementary Concept]
- A 308165 [MeSH Supplementary Concept]
- AWD 140-190 [MeSH Supplementary Concept]
- Ac-Pro-NHMe [MeSH Supplementary Concept]
- BI 99179 [MeSH Supplementary Concept]
- BMS 346 [MeSH Supplementary Concept]
- CIDD-0067106 [MeSH Supplementary Concept]
- CL 242817 [MeSH Supplementary Concept]
- CM544 [MeSH Supplementary Concept]
- DBD-beta-proline [MeSH Supplementary Concept]
- GPGPGP peptide [MeSH Supplementary Concept]
- GZR 123 [MeSH Supplementary Concept]
- IKH 12 [MeSH Supplementary Concept]
- IPR19 compound [MeSH Supplementary Concept]
- L-proline trichloroacetate [MeSH Supplementary Concept]
- LN-((2,3-dinitroglyceryl)fullerenyl)proline, methyl ester [MeSH Supplementary Concept]
- LN-((2-nitroglyceryl)fullerenyl)proline, methyl ester [MeSH Supplementary Concept]
- LY52 compound [MeSH Supplementary Concept]
- MC 838 [MeSH Supplementary Concept]
- N'-benzyl-N'-prolyl proline hydrazide [MeSH Supplementary Concept]
- N(alpha)-carbobenzoxypyroglutamic acid [MeSH Supplementary Concept]
- N,N',N-bis(methyl-L-prolinate) [MeSH Supplementary Concept]
- N,N-bis(carboxymethyl)aminoacetylproline [MeSH Supplementary Concept]
- N-(1(S)-carboxy-(4-hydroxy-3-iodophenyl)ethyl)-alanylproline [MeSH Supplementary Concept]
- N-(1-deoxy-beta-d-fructopyranos-1-yl)-l-proline [MeSH Supplementary Concept]
- N-(2-(3-phenyl-2-propenoylamino)propanoyl)proline [MeSH Supplementary Concept]
- N-(2-Nitrophenyl)proline [MeSH Supplementary Concept]
- N-(2-chloroethyl)-N-carbamoylprolinamide [MeSH Supplementary Concept]
- N-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-(2-((((1,1-dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexan-2-carboxamide [MeSH Supplementary Concept]
- N-(4-(2-(2-((2-dmethylaminoethyl)methylamino)ethylaminocarbonyl)pyrrolidinylsulfonyl)-2-nitrophenylamino)-N'-diphenylmethylthiourea [MeSH Supplementary Concept]
- N-(4-chlorobenzyl)-4-(2-(2-cyclohexylamino-1,2-dioxoethyl)pyrrolidin-1-yl)-4-oxobutanamide [MeSH Supplementary Concept]
- N-(4-nitrophenyl)-4-hydroxyproline [MeSH Supplementary Concept]
- N-(4-nitrophenyl)proline [MeSH Supplementary Concept]
- N-(9-fluorenylmethoxycarbonyl)-4-methylproline [MeSH Supplementary Concept]
- N-(N'-(2'-nitrophenyl)thiocarbamyl)pyrrolidine-2-carboxylic acid [MeSH Supplementary Concept]
- N-(aminoethyl)proline [MeSH Supplementary Concept]
- N-1-deoxyfructosyl-5-oxoproline [MeSH Supplementary Concept]
- N-Boc-(R)-silaproline [MeSH Supplementary Concept]
- N-acetyl-L-proline [MeSH Supplementary Concept]
- N-acetyl-tauryl-proline methylamide [MeSH Supplementary Concept]
- N-acetylprolinamide [MeSH Supplementary Concept]
- N-acetylproline [MeSH Supplementary Concept]
- N-acetylproline N-methylamide [MeSH Supplementary Concept]
- N-acetylproline-N',N'-dimethylamide [MeSH Supplementary Concept]
- N-benzyl-2,5-bis(methoxycarbonyl)pyrrolidine [MeSH Supplementary Concept]
- N-benzyl-L-proline [MeSH Supplementary Concept]
- N-benzyloxycarbonyl-3-O-tert-butyldimethylsilyl-5-hydroxyhomoproline [MeSH Supplementary Concept]
- N-benzyloxycarbonyl-L-prolyl-L-prolinal [MeSH Supplementary Concept]
- N-benzyloxycarbonyl-prolyl-3-fluoropyrrolidine [MeSH Supplementary Concept]
- N-biphenyl-2-yl-1-(((1-methyl-1H-benzimidazol-2-yl)sulfanyl)acetyl)prolinamide [MeSH Supplementary Concept]
- N-cinnamoyl-L-proline [MeSH Supplementary Concept]
- N-dithiocarboxyproline [MeSH Supplementary Concept]
- N-dodecyl-1-(pyrrolidine-2-carbonyl)pyrrolidine-2-carboxamide [MeSH Supplementary Concept]
- N-ethylcarbaminomethyl-L-proline [MeSH Supplementary Concept]
- N-heptafluorobutyrylproline [MeSH Supplementary Concept]
- N-lauroylproline [MeSH Supplementary Concept]
- N-methacryloyl-hydroxyproline [MeSH Supplementary Concept]
- N-methoxycarbonyl-proline-N'-methylamide [MeSH Supplementary Concept]
- N-methylproline [MeSH Supplementary Concept]
- N-retinoylproline [MeSH Supplementary Concept]
- N-tert-butoxycarbonyl-4-difluoromethylproline [MeSH Supplementary Concept]
- N-tert-butoxycarbonyl-4-trifluoromethylproline [MeSH Supplementary Concept]
- N-tert-butyloxycarbonylpyrrolidine-2-carboxylic acid (2'-(4-trimethoxysilylbenzylamide)cyclohexyl)amide [MeSH Supplementary Concept]
- N-trifluoroacetylproline anhydride [MeSH Supplementary Concept]
- N-trifluoroacetylprolyl chloride [MeSH Supplementary Concept]
- N-tritylprolinal [MeSH Supplementary Concept]
- N1-(2-(t-butyl)-4'-methyl-(4,5'-bithiazol)- 2'-yl)pyrrolidine-1,2-dicarboxamide [MeSH Supplementary Concept]
- N2-fluorenylmethoxycarbonyl-4-hydroxyproline allyl ester [MeSH Supplementary Concept]
- PPXY ligand [MeSH Supplementary Concept]
- RO5461111 [MeSH Supplementary Concept]
- RP 66803 [MeSH Supplementary Concept]
- SDZ NKT 343 [MeSH Supplementary Concept]
- SIG1459 [MeSH Supplementary Concept]
- SQ 27786 [MeSH Supplementary Concept]
- SQ 28853 [MeSH Supplementary Concept]
- VRC3375 [MeSH Supplementary Concept]
- XL019 compound [MeSH Supplementary Concept]
- acryloylproline methyl ester [MeSH Supplementary Concept]
- alpha,alpha-diphenylprolinol trimethylsilyl ether [MeSH Supplementary Concept]
- alpha-methyl-beta-proline [MeSH Supplementary Concept]
- aminoproline [MeSH Supplementary Concept]
- avorelin [MeSH Supplementary Concept]
- benzyl 5-carboxy-4-ethyl-3-methylpyrrole-2-carboxylate [MeSH Supplementary Concept]
- benzyl N-tert-butoxycarbonyl-4-oxo-prolinate [MeSH Supplementary Concept]
- benzyloxycarbonylproline [MeSH Supplementary Concept]
- benzyloxycarbonylproline N-methylamide [MeSH Supplementary Concept]
- beta-(1,4)-L-arabinosyl-(2S,4R)-4-hydroxyproline [MeSH Supplementary Concept]
- beta-proline [MeSH Supplementary Concept]
- bicycloproline [MeSH Supplementary Concept]
- bis(4-acetamidophenyl) 1-prolylpyrrolidine-2-phosphonate [MeSH Supplementary Concept]
- bis-L-proline hydrogen nitrate [MeSH Supplementary Concept]
- bulgecin A [MeSH Supplementary Concept]
- carbobenzoxyproline [MeSH Supplementary Concept]
- ceronapril [MeSH Supplementary Concept]
- chlorambucyl-proline [MeSH Supplementary Concept]
- chromaproline [MeSH Supplementary Concept]
- crilvastatin [MeSH Supplementary Concept]
- cyclo(L-Pro)3 [MeSH Supplementary Concept]
- cycloanthranilylproline [MeSH Supplementary Concept]
- danicopan [MeSH Supplementary Concept]
- danoprevir [MeSH Supplementary Concept]
- dansylproline [MeSH Supplementary Concept]
- deldeprevir [MeSH Supplementary Concept]
- delta(1)-pyrrolidine-2-carboxylic acid [MeSH Supplementary Concept]
- dichlorobis(DL-proline-kappaO)zinc(II) [MeSH Supplementary Concept]
- dihydroanatoxin-A [MeSH Supplementary Concept]
- dinitrophenyl-proline-N-hydroxysuccinimide ester [MeSH Supplementary Concept]
- diphenylprolinol silyl ether [MeSH Supplementary Concept]
- dirhodium tetrakis(S-(N-dodecylbenzenesulfonyl)prolinate) [MeSH Supplementary Concept]
- efpeglenatide [MeSH Supplementary Concept]
- ethyl 3-(ethoxycarbonyloxy)-2-(1-(4-tolylsulfinyl)cyclopropyl)-1-pyrrolidinecarboxylate [MeSH Supplementary Concept]
- ethyl 4-(1-(2-(hydrazinecarbonothioyl)hydrazono)ethyl)-3,5-dimethyl-1H-pyrrole-2-carboxylate [MeSH Supplementary Concept]
- ethyl tumonoate A [MeSH Supplementary Concept]
- faldaprevir [MeSH Supplementary Concept]
- fluoro-proline [MeSH Supplementary Concept]
- fuligocandin A [MeSH Supplementary Concept]
- fuligocandin B [MeSH Supplementary Concept]
- gamma-(4S)-trifluoromethyl proline [MeSH Supplementary Concept]
- glecaprevir [MeSH Supplementary Concept]
- glycine-alpha-methyl-proline [MeSH Supplementary Concept]
- glycyl-prolyl-glycyl-glycine [MeSH Supplementary Concept]
- homoproline [MeSH Supplementary Concept]
- hygronium [MeSH Supplementary Concept]
- methyl 1-(5-((3,3-difluoropyrrolidin-1-yl)carbonyl)pyrrolidin-3-yl)-1H-1,2,3-triazole-4-carboxylate [MeSH Supplementary Concept]
- methyl N-acetyl-4-fluoroproline [MeSH Supplementary Concept]
- methyl N-acetylproline [MeSH Supplementary Concept]
- narlaprevir [MeSH Supplementary Concept]
- nirmatrelvir [MeSH Supplementary Concept]
- nirmatrelvir and ritonavir drug combination [MeSH Supplementary Concept]
- ombitasvir [MeSH Supplementary Concept]
- paritaprevir [MeSH Supplementary Concept]
- penarolide sulfate A2 [MeSH Supplementary Concept]
- phenyl-L-proline [MeSH Supplementary Concept]
- phenylproline methyl ester [MeSH Supplementary Concept]
- pidobenzone [MeSH Supplementary Concept]
- pivaloyl-proline N-methylamide [MeSH Supplementary Concept]
- prolinal [MeSH Supplementary Concept]
- prolinamide [MeSH Supplementary Concept]
- proline N-carboxyanhydride [MeSH Supplementary Concept]
- proline benzyl ester [MeSH Supplementary Concept]
- proline cetyl ester [MeSH Supplementary Concept]
- proline thiohydantoin [MeSH Supplementary Concept]
- proline-nitric oxide [MeSH Supplementary Concept]
- prolinedithiocarbamate [MeSH Supplementary Concept]
- prolyl-1-piperazinylacetic acid [MeSH Supplementary Concept]
- prolyl-4-piperidinylacetic acid [MeSH Supplementary Concept]
- prolyl-beta-naphthylamide [MeSH Supplementary Concept]
- prolyl-glycyl-proline [MeSH Supplementary Concept]
- prolylrapamycin [MeSH Supplementary Concept]
- prophalan [MeSH Supplementary Concept]
- pseudoproline [MeSH Supplementary Concept]
- pyrimine [MeSH Supplementary Concept]
- pyrrolostatin [MeSH Supplementary Concept]
- selenaproline [MeSH Supplementary Concept]
- silaproline [MeSH Supplementary Concept]
- siloxyproline [MeSH Supplementary Concept]
- sodium N-dodecanoyl-L-prolinate [MeSH Supplementary Concept]
- stachydrine [MeSH Supplementary Concept]
- succinylproline [MeSH Supplementary Concept]
- tetrakis-dirhodium(II)-(S)-N-(n-perfluorooctylsulfonyl)prolinate [MeSH Supplementary Concept]
- thiazolidine-2-carboxylic acid [MeSH Supplementary Concept]
- thioproline dithiocarbamate [MeSH Supplementary Concept]
- tryptophyl-proline [MeSH Supplementary Concept]
- tumonoic acid D [MeSH Supplementary Concept]
- vaniprevir [MeSH Supplementary Concept]
- vixotrigine [MeSH Supplementary Concept]
- voxilaprevir [MeSH Supplementary Concept]
- zn-proline [MeSH Supplementary Concept]
See also (suggested by CISMeF)
- hyperprolinemia type 2 [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Proline [FMA entity]
- Proline [NCIt concept]
- Proline [LOINC component]
- Proline (substance) [SNOMED CT concept]
- proline [Substance BNPC]
- proline [SNOMED Notion]

Keyword's position in hierarchy(ies) :

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