mechlorethamine

Preferred Label : mechlorethamine;

MeSH definition : A biologic alkylating agent that exerts its cytotoxic effects by forming DNA ADDUCTS and DNA interstrand crosslinks, thereby inhibiting rapidly proliferating cells. The hydrochloride is an antineoplastic agent used to treat HODGKIN DISEASE and LYMPHOMA.;

MeSH synonym : chlormethine; mustine; nitrogen mustard; chlorethazine; bis(2-chloroethyl)methylamine; methylchlorethamine;

CISMeF synonym : 55-86-7 (Mechlorethamine hydrochloride); N-Oxide, mechlorethamine; genopharm brand of mechlorethamine hydrochloride; oxide, mechlorethamine; merck brand of mechlorethamine hydrochloride; merck frosst brand of mechlorethamine hydrochloride;

MeSH hyponym : NSC-10107; embichin; mustargen; nitrogranulogen; cloramin; mechlorethamine N-Oxide; caryolysine; NSC-762; mitomen; mechlorethamine hydrochloride N-Oxide; nitromin; mechlorethamine oxide; mechlorethamine hydrochloride; Hydrochloride, Mechlorethamine; Hydrochloride N-Oxide, Mechlorethamine; Mechlorethamine Hydrochloride N Oxide; N-Oxide, Mechlorethamine Hydrochloride; NSC 762; NSC762; NSC 10107; NSC10107; Mechlorethamine N Oxide; Nitrogen Mustard N-Oxide; N-Oxide, Nitrogen Mustard; Nitrogen Mustard N Oxide;

MeSH CAS label : ethanamine, 2-chloro-N-(2-chloroethyl)-N-methyl-;

MeSH Related Number : mechlorethamine hydrochloride; mechlorethamine hydrochloride N-Oxide; mechlorethamine N-Oxide; 126-85-2 (N-oxide); 302-70-5 (N-oxide, HCl); 55-86-7 (HCl); L0MR697HHI; 51-75-2;

Registry Number MeSH : 51-75-2;

Related CAS MeSH : 302-70-5 (Mechlorethamine hydrochloride N-Oxide); 126-85-2 (Mechlorethamine N-Oxide); L0MR697HHI (Mechlorethamine hydrochloride);

Wikipedia link : https://en.wikipedia.org/wiki/Bis(2-chloroethyl)methylamine;

Codes EINECS : 200-120-5;

Is substance : O;

UNII : 50D9XSG0VR;

Details

Origin ID

D008466;

UMLS CUI

C0025033;

ATC code(s)
- chlormethine [ATC Code]
Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analogs and derivatives [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- economics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Mechlorethamine [ICHI extension code]
- Mustard nitrogen [ICD-11 Extension code]
- Mustard nitrogen [ICHI extension code]
- Mustine [ICHI extension code]
- Nitrogen Mustard Compound [NCIt concept]
- nitrogen mustard analogues [ATC Code]
CISMeF manual mappings
- mechlorethamine [Substance BNPC]
Fils d'après SNOMED CT
- alkylating agents [MeSH Descriptor]
Pharmacological action(s)
- antineoplastic agents, alkylating [MeSH Descriptor]
- chemical warfare agents [MeSH Descriptor]
- irritants [MeSH Descriptor]
- riot control agents, chemical [MeSH Descriptor]
Record concept(s)
- NSC-10107 [MeSH concept]
- NSC-762 [MeSH concept]
- caryolysine [MeSH concept]
- cloramin [MeSH concept]
- embichin [MeSH concept]
- mechlorethamine [MeSH concept]
- mechlorethamine N-Oxide [MeSH concept]
- mechlorethamine hydrochloride [MeSH concept]
- mechlorethamine hydrochloride N-Oxide [MeSH concept]
- mechlorethamine oxide [MeSH concept]
- mitomen [MeSH concept]
- mustargen [MeSH concept]
- nitrogranulogen [MeSH concept]
- nitromin [MeSH concept]
Related MeSH Supplementary Concept(s)
- 4-(methylsulfinyl)phenyl nitrogen mustard [MeSH Supplementary Concept]
- AKO4 compound [MeSH Supplementary Concept]
- BACON protocol [MeSH Supplementary Concept]
- MABOP protocol [MeSH Supplementary Concept]
- MADDOC protocol [MeSH Supplementary Concept]
- MOFK protocol [MeSH Supplementary Concept]
- MOMK protocol [MeSH Supplementary Concept]
- MOP protocol [MeSH Supplementary Concept]
- MOP-BAP protocol [MeSH Supplementary Concept]
- MOPA-6 protocol [MeSH Supplementary Concept]
- MOPP protocol [MeSH Supplementary Concept]
- MOPP-ABV protocol [MeSH Supplementary Concept]
- MOPP-Bleo protocol [MeSH Supplementary Concept]
- MOPPEBVCAD protocol [MeSH Supplementary Concept]
- MVPP protocol [MeSH Supplementary Concept]
- MVVPP protocol [MeSH Supplementary Concept]
- ProMACE-MOPP protocol [MeSH Supplementary Concept]
- stanford V protocol [MeSH Supplementary Concept]
See also (suggested by CISMeF)
- mycosis fungoides [MeSH Descriptor]
See also inter- (CISMeF)
- Mechlorethamine hydrochloride (product) [Inactive SNOMED CT concept]
- Mustine [ICD-11 Extension code]
- Mustine poisoning (disorder) [SNOMED CT concept]
- Product containing chlormethine (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Hazardous or Poisonous Substance [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Chlormethine [ICD-11 Extension code]
- Chlormethine (substance) [SNOMED CT concept]
- Mechlorethamine [NCIt concept]
- Product containing chlormethine (medicinal product) [SNOMED CT concept]
- chlormethine [ATC Code]
- mechlorethamine [Substance BNPC]
- mechlorethamine [SNOMED Notion]
- nitrogen mustards [IUPAC Term]

Keyword's position in hierarchy(ies) :

Main resources

You can consult :

recommendations
documents concerning education
documents for patients