Mechlorethamine

Preferred Label : Mechlorethamine;

NCIt synonyms : ethanamine,2-chloro-N-(2-chloroethyl)-N-methyl; chlorethazine; methylchlorethamine; Mustine; Bis(2-chloroethyl)methylamine; Mustard; Methylbis(beta-chloroethyl)amine; HN 2; Nitrogen Mustard; chloromethine; Chlormethine;

NCIt related terms : NITROGEN MUSTARD HN-2; HN2;

NCIt definition : A synthetic agent related to sulphur mustard with antineoplastic and immunosuppressive properties. Nitrogen mustard (a member of a family of chemotherapy agents including cyclophosphamide and chlorambucil) is an irritant and carcinogenic agent metabolized to a highly reactive ethylene immonium derivative; the ethylene immonium derivative alkylates DNA and inhibits DNA replication. This agent also exhibits lympholytic properties. (NCI04);

Alternative definition : CDISC: The nitrogen mustard vesicant HN-2.;

UNII : 50D9XSG0VR;

InChIKey : HAWPXGHAZFHHAD-UHFFFAOYSA-N;

CAS number : 51-75-2;

Chemical formula : C5H11Cl2N;

ChEBI ID : CHEBI:28925;

Codes from synonyms : NSC0000762; 322;

Details

Origin ID

C62056;

UMLS CUI

C0025033;

Automatic exact mappings (from CISMeF team)
- Mechlorethamine [ICHI extension code]
- Mustard [SNOMED Notion]
- Mustard [LOINC component]
- Mustard (emetic) [ICD-11 Extension code]
- Mustard (substance) [SNOMED CT concept]
- Mustard nitrogen [ICD-11 Extension code]
- Mustard nitrogen [ICHI extension code]
- Mustine [ICHI extension code]
- mustard [MeSH concept]
- mustard compounds [MeSH Descriptor]
- mustards [IUPAC Term]
- nitrogen mustard compounds [MeSH Descriptor]
See also inter- (CISMeF)
- Mechlorethamine hydrochloride (product) [Inactive SNOMED CT concept]
- Mustine [ICD-11 Extension code]
- Product containing chlormethine (medicinal product) [SNOMED CT concept]
- mustard plant [MeSH Descriptor]
Semantic type(s)
- Hazardous or Poisonous Substance [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Chlormethine [ICD-11 Extension code]
- Chlormethine (substance) [SNOMED CT concept]
- Product containing chlormethine (medicinal product) [SNOMED CT concept]
- chlormethine [ATC Code]
- mechlorethamine [Substance BNPC]
- mechlorethamine [MeSH concept]
- mechlorethamine [MeSH Descriptor]
- mechlorethamine [SNOMED Notion]
- nitrogen mustards [IUPAC Term]
Validated automatic mappings to BTNT
- Chlormethine hydrochloride [Substance BNPC]
- Chlormethine hydrochloride (substance) [SNOMED CT concept]
- chlormethine [ATC Code]
- mechlorethamine hydrochloride [SNOMED Notion]
- mechlorethamine hydrochloride [MeSH concept]
concept_is_in_subset
- CDISC SEND Chemical Challenge Agent Name Response Terminology [NCIt concept]
- CDISC SEND Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HL Authorized Value Terminology [NCIt concept]
- HL Protocol Treatment Modifications Table [NCIt concept]
- HL Total Dose Table [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Mechlorethamine Hydrochloride [NCIt concept]
is_component_of_chemotherapy_regimen
- Topical Clobetasol/Mechlorethamine Regimen [NCIt concept]
is_free_acid_or_base_form_of
- Mechlorethamine Hydrochloride [NCIt concept]

Keyword's position in hierarchy(ies) :

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