" /> Mechlorethamine Hydrochloride - CISMeF





Preferred Label : Mechlorethamine Hydrochloride;

NCIt synonyms : chlorethamine hydrochloride; HN 2 Hydrochloride; mechlorethamine HCl; Mustargen Hydrochloride; Methylchlorethamine Hydrochloride; Chlorethazine Hydrochloride; Chlormethine Hydrochloride; Mustargen HCl; Chlorethamine HCl; ethanamine,2-chloro-N-(2-chloroethyl)-N-methyl Hydrochloride; Chloromethine Hydrochloride; Chloromethine HCl; Bis(2-chloroethyl)methylamine Hydrochloride; Methylbis(beta-chloroethyl)amine Hydrochloride; Nitrogen Mustard;

NCIt related terms : Mustargen; Caryolysine; mustine; Mustine hydrochloride; N-Lost; Erasol;

NCIt definition : The hydrochloride salt of mechlorethamine, a nitrogen mustard and an analogue of sulfur mustard, with antineoplastic and immunosuppressive activities. Mechlorethamine is metabolized to an unstable, highly reactive ethyleniminium intermediate that alkylates DNA, particularly the 7 nitrogen of guanine residues, resulting in DNA base pair mismatching, DNA interstrand crosslinking, the inhibition of DNA repair and synthesis, cell-cycle arrest, and apoptosis. This agent also exhibits lympholytic properties.;

Alternative definition : NCI-GLOSS: A drug used to treat some types of cancer and some skin conditions that may become cancer. It attaches to the cell's DNA and may kill cancer cells. Mechlorethamine hydrochloride is a type of alkylating agent.;

UNII : L0MR697HHI;

InChIKey : QZIQJVCYUQZDIR-UHFFFAOYSA-N;

CAS number : 55-86-7;

Drug name : Cloramin; Mustine Hydrochloride; Caryolysine; Erasol; Onco-Cloramin; Mustargen;

Molecule name : WR-147650;

Chemical formula : C5H11Cl2N.HCl;

NSC code : 762;

ChEBI ID : CHEBI:55368;

Codes from synonyms : CDR0000413950; NSC0000762; CDR0000046603; 03114; CDR0000476625;

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29/05/2025


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