Preferred Label : leukoencephalopathy, progressive multifocal;
MeSH definition : An opportunistic viral infection of the central nervous system associated with conditions
that impair cell-mediated immunity (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME and other
IMMUNOLOGIC DEFICIENCY SYNDROMES; HEMATOLOGIC NEOPLASMS; IMMUNOSUPPRESSION; and COLLAGEN
DISEASES). The causative organism is JC Polyomavirus (JC VIRUS) which primarily affects
oligodendrocytes, resulting in multiple areas of demyelination. Clinical manifestations
include DEMENTIA; ATAXIA; visual disturbances; and other focal neurologic deficits,
generally progressing to a vegetative state within 6 months. (From Joynt, Clinical
Neurology, 1996, Ch26, pp36-7);
MeSH synonym : progressive multifocal leukoencephalopathy; jc polyomavirus encephalitis; multifocal leukoencephalopathy, progressive; multifocal leukoencephalopathies, progressive; encephalitis, jc polyomavirus; leukoencephalopathies, progressive multifocal; progressive multifocal leukoencephalopathies; jc polyomavirus encephalopathy; encephalopathies, jc polyomavirus; encephalopathy, jc polyomavirus;
Wikipedia link : https://en.wikipedia.org/wiki/Leukoencephalopathy, progressive multifocal;
Origin ID : D007968;
UMLS CUI : C0023524;
Allowable qualifiers
Currated CISMeF NLP mapping
DO Cross reference
ORDO relation(s)
Record concept(s)
See also (suggested by CISMeF)
Semantic type(s)
UMLS correspondences (same concept)
An opportunistic viral infection of the central nervous system associated with conditions
that impair cell-mediated immunity (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME and other
IMMUNOLOGIC DEFICIENCY SYNDROMES; HEMATOLOGIC NEOPLASMS; IMMUNOSUPPRESSION; and COLLAGEN
DISEASES). The causative organism is JC Polyomavirus (JC VIRUS) which primarily affects
oligodendrocytes, resulting in multiple areas of demyelination. Clinical manifestations
include DEMENTIA; ATAXIA; visual disturbances; and other focal neurologic deficits,
generally progressing to a vegetative state within 6 months. (From Joynt, Clinical
Neurology, 1996, Ch26, pp36-7)
https://ansm.sante.fr/informations-de-securite/tecfidera-et-risque-de-leucoencephalopathie-multifocale-progressive-actualisation-des-recommandations
2020
false
false
false
France
French
guidelines for drug use
pharmacovigilance note
leukoencephalopathy, progressive multifocal
Dimethyl Fumarate
Dimethyl Fumarate
lymphopenia
drug monitoring
dimethyl fumarate
lymphocytes
---
Summary Safety Review - GILENYA (fingolimod) - Assessing the Potential Risk of a Rare
Brain Infection (Progressive Multifocal Leukoencephalopathy)
https://www.hc-sc.gc.ca/dhp-mps/medeff/reviews-examens/gilenya2-fra.php
2016
false
false
false
Canada
French
English
drug evaluation
pharmacovigilance note
leukoencephalopathy, progressive multifocal
Fingolimod Hydrochloride
administration, oral
fingolimod
immunosuppressive agents
risk assessment
multiple sclerosis, relapsing-remitting
adult
---
ECFIDERA (dimethyl fumarate) - Risk of Rare Brain Condition Known as Progressive Multifocal
Leukoencephalopathy (PML) - For Health Professionals
https://canadiensensante.gc.ca/recall-alert-rappel-avis/hc-sc/2015/43625a-fra.php
https://canadiensensante.gc.ca/recall-alert-rappel-avis/hc-sc/2015/43627a-fra.php
2015
false
false
false
Canada
French
English
pharmacovigilance note
multiple sclerosis, relapsing-remitting
risk
leukoencephalopathy, progressive multifocal
lymphopenia
drug monitoring
immunologic factors
Dimethyl Fumarate
dimethyl fumarate
---
https://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2014/39189a-fra.php
https://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2014/39191a-fra.php
2014
Canada
French
belimumab
infusions, intravenous
belimumab
lupus erythematosus, systemic
leukoencephalopathy, progressive multifocal
immunosuppressive agents
pharmacovigilance note
patient education handout
antibodies, monoclonal, humanized
---
http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=FR&Expert=217260
2011
France
scientific and technical information
leukoencephalopathy, progressive multifocal
---
https://www.healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2010/14090a-fra.php
https://www.healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2010/14629a-fra.php
2010
false
Canada
English
French
Natalizumab
Natalizumab
natalizumab
leukoencephalopathy, progressive multifocal
multiple sclerosis
continuity of patient care
pharmacovigilance note
---
https://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2008/14527a-fra.php
https://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2009/14583a-fra.php
2009
false
Canada
French
English
Natalizumab
leukoencephalopathy, progressive multifocal
product surveillance, postmarketing
multiple sclerosis
pharmacovigilance note
---
https://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2009/14575a-fra.php
2009
false
Canada
English
French
Rituximab
antirheumatic agents
leukoencephalopathy, progressive multifocal
arthritis, rheumatoid
pharmacovigilance note
---
https://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2008/14514a-fra.php
2008
Canada
French
English
antibodies, monoclonal
psoriasis
leukoencephalopathy, progressive multifocal
adult
Infections
canada
efalizumab
antibodies, monoclonal
pharmacovigilance note
---
http://afssaps.sante.fr/Infos-de-securite/Lettres-aux-professionnels-de-sante/Cas-de-leucoencephalopathie-multifocale-progressive-LEMP-observes-chez-des-patients-atteints-de-lupus-erythemateux-dissemine-LED-ou-de-vascularite-et-traites-par-MabThera-R-utilisation-hors-AMM
2007
false
France
French
Rituximab
antineoplastic agents
leukoencephalopathy, progressive multifocal
arthritis, rheumatoid
antirheumatic agents
lymphoma, Non-Hodgkin
pharmacovigilance note
---