Preferred Label : leukoencephalopathy, progressive multifocal;

MeSH definition : An opportunistic viral infection of the central nervous system associated with conditions that impair cell-mediated immunity (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME and other IMMUNOLOGIC DEFICIENCY SYNDROMES; HEMATOLOGIC NEOPLASMS; IMMUNOSUPPRESSION; and COLLAGEN DISEASES). The causative organism is JC Polyomavirus (JC VIRUS) which primarily affects oligodendrocytes, resulting in multiple areas of demyelination. Clinical manifestations include DEMENTIA; ATAXIA; visual disturbances; and other focal neurologic deficits, generally progressing to a vegetative state within 6 months. (From Joynt, Clinical Neurology, 1996, Ch26, pp36-7);

MeSH synonym : progressive multifocal leukoencephalopathy; jc polyomavirus encephalitis; multifocal leukoencephalopathy, progressive; multifocal leukoencephalopathies, progressive; encephalitis, jc polyomavirus; leukoencephalopathies, progressive multifocal; progressive multifocal leukoencephalopathies; jc polyomavirus encephalopathy; encephalopathies, jc polyomavirus; encephalopathy, jc polyomavirus;

Wikipedia link : https://en.wikipedia.org/wiki/Leukoencephalopathy, progressive multifocal;

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An opportunistic viral infection of the central nervous system associated with conditions that impair cell-mediated immunity (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME and other IMMUNOLOGIC DEFICIENCY SYNDROMES; HEMATOLOGIC NEOPLASMS; IMMUNOSUPPRESSION; and COLLAGEN DISEASES). The causative organism is JC Polyomavirus (JC VIRUS) which primarily affects oligodendrocytes, resulting in multiple areas of demyelination. Clinical manifestations include DEMENTIA; ATAXIA; visual disturbances; and other focal neurologic deficits, generally progressing to a vegetative state within 6 months. (From Joynt, Clinical Neurology, 1996, Ch26, pp36-7)

https://ansm.sante.fr/informations-de-securite/tecfidera-et-risque-de-leucoencephalopathie-multifocale-progressive-actualisation-des-recommandations
2020
false
false
false
France
French
guidelines for drug use
pharmacovigilance note
leukoencephalopathy, progressive multifocal
Dimethyl Fumarate
Dimethyl Fumarate
lymphopenia
drug monitoring
dimethyl fumarate
lymphocytes

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Summary Safety Review - GILENYA (fingolimod) - Assessing the Potential Risk of a Rare Brain Infection (Progressive Multifocal Leukoencephalopathy)
https://www.hc-sc.gc.ca/dhp-mps/medeff/reviews-examens/gilenya2-fra.php
2016
false
false
false
Canada
French
English
drug evaluation
pharmacovigilance note
leukoencephalopathy, progressive multifocal
Fingolimod Hydrochloride
administration, oral
fingolimod
immunosuppressive agents
risk assessment
multiple sclerosis, relapsing-remitting
adult

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ECFIDERA (dimethyl fumarate) - Risk of Rare Brain Condition Known as Progressive Multifocal Leukoencephalopathy (PML) - For Health Professionals
https://canadiensensante.gc.ca/recall-alert-rappel-avis/hc-sc/2015/43625a-fra.php
https://canadiensensante.gc.ca/recall-alert-rappel-avis/hc-sc/2015/43627a-fra.php
2015
false
false
false
Canada
French
English
pharmacovigilance note
multiple sclerosis, relapsing-remitting
risk
leukoencephalopathy, progressive multifocal
lymphopenia
drug monitoring
immunologic factors
Dimethyl Fumarate
dimethyl fumarate

---
https://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2014/39189a-fra.php
https://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2014/39191a-fra.php
2014
Canada
French
belimumab
infusions, intravenous
belimumab
lupus erythematosus, systemic
leukoencephalopathy, progressive multifocal
immunosuppressive agents
pharmacovigilance note
patient education handout
antibodies, monoclonal, humanized

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http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=FR&Expert=217260
2011
France
scientific and technical information
leukoencephalopathy, progressive multifocal

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https://www.healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2010/14090a-fra.php
https://www.healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2010/14629a-fra.php
2010
false
Canada
English
French
Natalizumab
Natalizumab
natalizumab
leukoencephalopathy, progressive multifocal
multiple sclerosis
continuity of patient care
pharmacovigilance note

---
https://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2008/14527a-fra.php
https://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2009/14583a-fra.php
2009
false
Canada
French
English
Natalizumab
leukoencephalopathy, progressive multifocal
product surveillance, postmarketing
multiple sclerosis
pharmacovigilance note

---
https://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2009/14575a-fra.php
2009
false
Canada
English
French
Rituximab
antirheumatic agents
leukoencephalopathy, progressive multifocal
arthritis, rheumatoid
pharmacovigilance note

---
https://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2008/14514a-fra.php
2008
Canada
French
English
antibodies, monoclonal
psoriasis
leukoencephalopathy, progressive multifocal
adult
Infections
canada
efalizumab
antibodies, monoclonal
pharmacovigilance note

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http://afssaps.sante.fr/Infos-de-securite/Lettres-aux-professionnels-de-sante/Cas-de-leucoencephalopathie-multifocale-progressive-LEMP-observes-chez-des-patients-atteints-de-lupus-erythemateux-dissemine-LED-ou-de-vascularite-et-traites-par-MabThera-R-utilisation-hors-AMM
2007
false
France
French
Rituximab
antineoplastic agents
leukoencephalopathy, progressive multifocal
arthritis, rheumatoid
antirheumatic agents
lymphoma, Non-Hodgkin
pharmacovigilance note

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28/04/2025


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