gene amplification

Preferred Label : gene amplification;

MeSH definition : A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.;

MeSH synonym : amplification, gene;

Wikipedia automatic translation : Gene duplication#Gene duplication as amplification;

MeSH annotation : for physiol process only; for technique use NUCLEIC ACID AMPLIFICATION TECHNIQUES or specifics;

Wikipedia link : https://en.wikipedia.org/wiki/Gene duplication#Gene duplication as amplification;

Details

Origin ID

D005784;

UMLS CUI

C0017256;

Allowable qualifiers
- drug effects [MeSH Qualifier]
- ethics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- immunology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- FGFR4 Gene Amplification [NCIt concept]
Currated CISMeF NLP mapping
- Gene Amplification [NCIt concept]
- Gene Amplification Abnormality [NCIt concept]
- Gene amplification (finding) [SNOMED CT concept]
- gene amplification [IUPAC Term]
- gene amplification [SNOMED Notion]
Record concept(s)
- gene amplification [MeSH concept]
Related MeSH term(s)
- nucleic acid amplification techniques [MeSH Descriptor]
See also
- gene dosage [MeSH Descriptor]
Semantic type(s)
- Genetic Function [UMLS semantic type]
UMLS correspondences (same concept)
- Gene Amplification [NCIt concept]
- Gene amplification (finding) [SNOMED CT concept]
- gene amplification [SNOMED Notion]

Keyword's position in hierarchy(ies) :

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