Preferred Label : dantrolene;
MeSH definition : Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling
in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities.
Although the mechanism of action is probably not central, dantrolene is usually grouped
with the central muscle relaxants.;
MeSH hyponym : dantrium; Dantrolene Sodium; Sodium, Dantrolene;
MeSH CAS label : 2,4-Imidazolidinedione, 1-(((5-(4-nitrophenyl)-2-furanyl)methylene)amino)-;
MeSH Related Number : 7261-97-4 (Dantrolene); dantrolene sodium; 287M0347EV;
Registry Number MeSH : 7261-97-4;
Related CAS MeSH : 287M0347EV (Dantrolene sodium);
Wikipedia link : https://en.wikipedia.org/wiki/Dantrolene;
Codes EINECS : 230-684-8;
Is substance : O;
UNII : F64QU97QCR;
InChIKey : OZOMQRBLCMDCEG-VIZOYTHASA-N;
Origin ID : D003620;
UMLS CUI : C0010976;
ATC code(s)
Allowable qualifiers
CISMeF manual mappings
Currated CISMeF NLP mapping
Pharmacological action(s)
Record concept(s)
Related MeSH Supplementary Concept(s)
- F 490 [MeSH Supplementary Concept]
Semantic type(s)
UMLS correspondences (same concept)
Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling
in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities.
Although the mechanism of action is probably not central, dantrolene is usually grouped
with the central muscle relaxants.
https://www.has-sante.fr/jcms/p_3589751/fr/agilus-dantrolene-sodique-hemiheptahydrate-anesthesie
2025
false
false
false
France
Dantrolene sodium, hemiheptahydrate
insurance, health, reimbursement
treatment outcome
adult
child
adolescent
Malignant hyperpyrexia caused by anesthetic (disorder)
anesthetics
malignant hyperthermia
infant
dantrolene
Product containing only dantrolene in parenteral dose form (medicinal product form)
evaluation of the transparency committee
Dantrolene Sodium
dantrolene
---
https://www.ema.europa.eu/en/medicines/human/EPAR/agilus
2025
false
false
false
Netherlands
French
English
treatment outcome
syndication feed
summary of product characteristics
package leaflet
drug evaluation
drug approval
europe
dantrolene
Dantrolene sodium, hemiheptahydrate
Dantrolene sodium, hemiheptahydrate
dantrolene
dantrolene
malignant hyperthermia
muscle relaxants, central
muscle relaxants, central
injections, intravenous
risk management
drug interactions
pregnancy
breast feeding
ryanodine receptor 1
ryanodine receptor calcium release channel
drug evaluation, preclinical
---
https://ansm.sante.fr/informations-de-securite/dantrium-r-intraveineux-lyophilisat-pour-preparation-injectable-dantrolene-sodique-20-mg-utilisation-dun-dispositif-de-filtration-a-usage-unique-fourni-avec-le-produit-pour-reduire-le-risque-de-reactions-au-site-dinjection
2019
false
false
false
France
French
dantrolene
Dantrolene Sodium
injections, intravenous
filtration
Injection Site Reaction
dantrolene
---
http://www.has-sante.fr/portail/jcms/c_2598659/fr/dantrium
http://www.has-sante.fr/portail/jcms/c_987204/dantrium
http://www.has-sante.fr/portail/jcms/c_400858/dantrium
2016
false
France
French
treatment outcome
Dantrolene Sodium
malignant hyperpyrexia due to anesthesia
dantrolene
administration, oral
capsules
dantrolene
muscle relaxants, central
insurance, health, reimbursement
muscle spasticity
malignant hyperthermia
evaluation of the transparency committee
---