Preferred Label : cyclophosphamide;

MeSH definition : Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.;

CISMeF synonym : 2H-1,3,2-Oxazaphosphorin-2-amine, N,N-bis(2-chloroethyl)tetrahydro-, 2-oxide; 60007-95-6 (Cyclophosphamide, ( -)-Isomer); 6055-19-2 (Cyclophosphamide monohydrate); cyclophosphamide, ( -)-Isomer; anhydrous, cyclophosphamide; cyclophosphamide monohydrate; cyclophosphane; cytophosphane; monohydrate, cyclophosphamide;

CISMeF acronym : B518;

DeCS synonym : B518;

MeSH hyponym : endoxan; procytox; sendoxan; cyclophosphamide anhydrous; neosar; cyclophosphamide, (S)-Isomer; NSC-26271; cyclophosphamide, (R)-Isomer; cytophosphan; B-518; B 518; B518; NSC 26271; NSC26271;

Related MeSH term : cytoxan;

MeSH CAS label : ( ,-)-2-(bis(2-Chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-Oxide monohydrate;

MeSH Related Number : cyclophosphamide, (S)-Isomer; cyclophosphamide, (R)-Isomer; 50-18-0 (Cyclophosphamide); 60007-96-7 ((S)-isomer); 60030-72-0 ((R)-isomer); cyclophosphamide anhydrous; 6UXW23996M;

Registry Number MeSH : 50-18-0;

Related CAS MeSH : 60030-72-0 (Cyclophosphamide, (R)-Isomer); 60007-96-7 (Cyclophosphamide, (S)-Isomer); 6UXW23996M (Cyclophosphamide anhydrous);

Wikipedia link : https://en.wikipedia.org/wiki/Cyclophosphamide;

Codes EINECS : 200-015-4;

Is substance : O;

medicament (CISMeF) : O;

UNII : 8N3DW7272P;

InChIKey : PWOQRKCAHTVFLB-UHFFFAOYSA-N;

Details


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You can consult :

Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.

https://www.has-sante.fr/jcms/p_3530407/fr/cyclophosphamide-accord-cyclophosphamide-cancer-et-maladies-auto-immunes
2024
false
false
false
France
treatment outcome
insurance, health, reimbursement
Product containing only cyclophosphamide in parenteral dose form (medicinal product form)
precursor cell lymphoblastic Leukemia-Lymphoma
cyclophosphamide
transplantation conditioning
multiple myeloma
hodgkin disease
lymphoma, Non-Hodgkin
ovarian neoplasms
breast neoplasms
neoplasm metastasis
sarcoma, ewing
small cell lung carcinoma
bronchial neoplasms
neuroblastoma
lupus nephritis
Granulomatosis with Polyangiitis
myeloablative agonists
antineoplastic agents, alkylating
immunosuppressive agents
evaluation of the transparency committee
cyclophosphamide
autoimmune diseases

---
https://www.rheuma-net.ch/fr/doc/cyclophosphamid-1/viewdocument/348
2024
Switzerland
guideline
cyclophosphamide
cyclophosphamide
Background Treatment
Cyclophosphamide

---
https://ansm.sante.fr/informations-de-securite/cyclophosphamide-reddy-pharma-500mg-1ml-1000mg-2ml-et-2000mg-4ml-solutions-a-diluer-pour-solution-injectable-pour-perfusion-cyclophosphamide-contre-indication-chez-les-enfants-et-les-adolescents-en-raison-de-la-teneur-en-alcool
2022
false
false
false
France
French
pharmacovigilance note
child
adolescent
infusions, intravenous
ethanol
cyclophosphamide
pharmaceutical solutions

---
Mise à disposition d'un hybride.
https://www.has-sante.fr/jcms/p_3324313/fr/cyclophosphamide-reddy-pharma-cyclophosphamide
2022
false
false
false
France
evaluation of the transparency committee
cyclophosphamide
cyclophosphamide

---
https://www.cochrane.org/fr/CD008084/INJ_quels-sont-les-benefices-et-les-risques-du-traitement-dun-empoisonnement-au-paraquat-par-une
2021
false
false
false
United Kingdom
France
pulmonary fibrosis
suicide
Paraquat toxicity (disorder)
Adrenocortical steroid therapy
Glucocorticoid therapy
corticosteroid therapy
meta-analysis
french abstract
cyclophosphamide
glucocorticoids
pulmonary fibrosis
paraquat

---
https://www.has-sante.fr/jcms/p_3287082/fr/syncardia-tah-t-70cc
2021
France
health technology assessment
antineoplastic combined chemotherapy protocols
cyclophosphamide
doxorubicin
medroxyprogesterone
middle cerebral artery
both cardiac ventricles
ACM protocol
antibodies, monoclonal
assisted circulation

---
http://www.has-sante.fr/portail/jcms/c_2627627/fr/endoxan
http://www.has-sante.fr/portail/jcms/c_400914/fr/endoxan-50-mg-comprime-enrobe-boite-de-50-comprimes-code-cip-303-589-0
2016
false
France
French
insurance, health, reimbursement
tablets
cyclophosphamide
administration, oral
antineoplastic agents, alkylating
cyclophosphamide
immunosuppressive agents
antirheumatic agents
treatment outcome
evaluation of the transparency committee

---
http://www.has-sante.fr/portail/jcms/c_2568269/fr/cyclophosphamide-sandoz
2015
false
false
false
France
French
evaluation of the transparency committee
cyclophosphamide
cyclophosphamide

---
http://www.lecrat.eu/?s=Etat+des+connaissances+sur+le+cyclophosphamide
France
drug information
teratogens
pregnancy, nos
knowledge
pregnancy, high-risk
cyclophosphamide

---
http://www.cnil.fr/fileadmin/documents/La_CNIL/publications/DEIP/CNIL_CAHIERS_IP2_WEB.pdf
2014
false
true
false
France
French
scientific and technical information
health
hong kong
M-2 protocol
dataset
human body
antineoplastic combined chemotherapy protocols
carmustine
cyclophosphamide
melphalan
prednisone
vincristine
dataset

---
http://www.cochrane.org/fr/CD002265
2013
false
true
false
United Kingdom
France
treatment outcome
cyclophosphamide
immunosuppressive agents
immunosuppressive agents
methylprednisolone
central nervous system agents
central nervous system agents
Neuropsychiatric lupus
review of literature
meta-analysis
french abstract
cyclophosphamide
methylprednisolone
lupus vasculitis, central nervous system

---
http://www.lecrat.eu/?s=Cyclophosphamide
2013
France
French
pregnancy
cyclophosphamide
immunosuppressive agents
antineoplastic agents, alkylating
infant, newborn
teratogens
mutagens
cyclophosphamide
drug information

---
http://www.cochrane.org/fr/CD006300/le-cyclophosphamide-compare-a-lifosfamide-dans-le-traitement-du-sarcome-chez-les-enfants-et-jeunes-adultes
2012
false
true
false
France
United Kingdom
French
review of literature
french abstract
osteosarcoma
cyclophosphamide
ifosfamide
antineoplastic agents, alkylating
treatment outcome
child
adolescent
young adult
comparative study
sarcoma

---
https://www.inspq.qc.ca/toxicologie-clinique/surveillance-environnementale-des-medicaments-dangereux-mise-jour-2011
2011
false
true
false
Canada
cyclophosphamide
occupational exposure
journal article
drug monitoring
environmental monitoring

---
https://hemato.chu-limoges.fr/hematolim/Portals/0/Info_patient/chimios/Fiche%20endoxan.pdf
2010
false
true
false
France
cyclophosphamide
popular works

---
http://www.aboutkidshealth.ca/Fr/HealthAZ/Drugs/Pages/Cyclophosphamide-For-Nephrotic-Syndrome.aspx
2010
false
Canada
French
English
secondary prevention
nephrotic syndrome
immunosuppressive agents
immunosuppressive agents
administration, oral
cyclophosphamide
cyclophosphamide
child
patient education handout
drug information

---
http://www.cochrane.org/fr/CD001157
2010
United Kingdom
France
French
review of literature
arthritis, rheumatoid
cyclophosphamide
treatment outcome
antirheumatic agents
french abstract

---
http://www.aboutkidshealth.ca/Fr/HealthAZ/Drugs/Pages/Cyclophosphamide.aspx
2008
Canada
popular works
drug information
cyclophosphamide
child

---
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25/04/2025


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