Preferred Label : histocompatibility antigens class ii;
MeSH definition : Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains
can be polymorphic although there is more structural variation in the beta chains.
The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene
on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the
H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells,
and sperm and are thought to mediate the competence of and cellular cooperation in
the immune response. The term IA antigens used to refer only to the proteins encoded
by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility
antigen.;
MeSH synonym : antigens, ia-like; antigen, i-a; class ii histocompatibility antigens; class ii antigens; class ii major histocompatibility antigens; antigen, ia; antigen, class ii; ia antigens; ia-like antigens; antigens, immune response; antigens, ia; i a antigen; immune-response-associated antigens; i-a antigen; class ii antigen; i-a-antigen; immune response associated antigens; antigens, immune-response-associated; ia like antigens; ia antigen; immune response antigens; antigens, class ii; MHC-II Molecules; MHC II Molecules; Molecules, MHC-II; MHC II Peptides; Peptides, MHC II; Class II MHC Proteins; MHC Class II Molecules; Class II Major Histocompatibility Molecules; Class II Major Histocompatibility Antigen; Ia-Like Antigen; Antigen, Ia-Like; Ia Like Antigen; MHC Class II Molecule; MHC II Peptide; II Peptide, MHC; Peptide, MHC II; Class II Histocompatibility Antigen;
MeSH Hyperonym : Immune-Associated antigens; Antigens, Immune-Associated; Immune Associated Antigens;
MeSH annotation : human & animal; GEN: prefer specifics; see also HLA ANTIGENS & specifics for human;
X ref IA ANTIGENS refers to any class II histocompatibility antigen; human & animal; see also HLA ANTIGENS & specifics for human;
Is substance : O;
Origin ID : D000949;
UMLS CUI : C0019630;
Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Indexing information
- Record concept(s)
- Related MeSH Supplementary Concept(s)
- See also
- Semantic type(s)
- UMLS correspondences (same concept)
Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains
can be polymorphic although there is more structural variation in the beta chains.
The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene
on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the
H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells,
and sperm and are thought to mediate the competence of and cellular cooperation in
the immune response. The term IA antigens used to refer only to the proteins encoded
by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility
antigen.
