MHC Class II Protein

Preferred Label : MHC Class II Protein;

NCIt synonyms : Class II MHC Protein; Histocompatibility Antigen, Class II; MHC Class II Molecule; Major Histocompatibility Complex Class II; MHC Class-II Protein;

NCIt related terms : human lymphocyte antigen; HLA; human leukocyte antigen;

NCIt definition : MHC Class-II Proteins are non-covalently linked polymorphic alpha/beta transmembrane glycoproteins. The immunological function of MHC Class-II proteins is to bind and present antigenic peptides on the surfaces of cells for recognition by the antigen-specific T cell receptors of lymphocytes. These proteins plays an important role in the mediation of immune response.;

Alternative definition : NCI-GLOSS: One of a group of proteins found on the surface of white blood cells and other cells that play an important part in the body's immune response to foreign substances. These antigens vary from person to person, and human leukocyte antigen tests are done before organ transplantation to find out if tissues match between a donor and a recipient.;

Codes from synonyms : CDR0000386209; CDR0000386211; CDR0000386210;

Details

Origin ID

C20705;

UMLS CUI

C0019630;

Automatic exact mappings (from CISMeF team)
- Class II major histocompatibility complex protein [FMA entity]
- HLA [LOINC component]
- HLA Ag [LOINC component]
- HLA antigens [LOINC Class]
- HLA antigens [MeSH concept]
- HLA antigens [MeSH Descriptor]
- HLA studies [LOINC component]
- HLA-A [LOINC component]
- HLA-A antigens [MeSH Descriptor]
- HLA-A locus [LOINC component]
- Human leukocyte antigen (substance) [SNOMED CT concept]
- Human leukocyte antigen A (substance) [SNOMED CT concept]
- Human leukocyte antigen present (finding) [Inactive SNOMED CT concept]
- Major histocompatibility complex class II (substance) [SNOMED CT concept]
- Major histocompatibility complex, class i, a [OMIM Phenotype]
Currated CISMeF NLP mapping
- histocompatibility antigens class II [MeSH concept]
- histocompatibility antigens class ii [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- histocompatibility antigens class II [MeSH concept]
- histocompatibility antigens class ii [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Immunoprotein Gene [NCIt concept]
- MHC Class II Gene [NCIt concept]
gene_product_expressed_in_tissue
- CD4-Positive T-Lymphocyte [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_chemical_classification
- HLA Complex [NCIt concept]
gene_product_has_structural_domain_or_motif
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Antigen Presentation [NCIt concept]
- Immune System Process [NCIt concept]
- Immunoregulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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