Major histocompatibility complex, class i, a

Preferred Label : Major histocompatibility complex, class i, a;

Obsolete resource : true;

Alternative titles and symbols : Hla-a; Hla-a histocompatibility typemajor histocompatibility complex, class i, h pseudogene; Hla-h; Major histocompatibility complex, class i, j pseudogene; Hla-j;

Description : The human major histocompatibility complex (MHC) has been divided into 3 regions on chromosome 6p21.3: class II (centromeric), class III, and class I (telomeric), with extended class I and class II regions on either side. The MHC encodes highly polymorphic proteins, many of which are associated with the immune system. The products of classical polymorphic class I genes, human leukocyte antigen-A (HLA-A), HLA-B (142830), and HLA-C (142840), interact with T-cell receptor (TCR; see 186880) molecules, as well as killer immunoglobulin-like receptors (KIRs; see 604936) expressed on natural killer cells and some T cells (review by Trowsdale, 2001). Evidence from amino acid sequences suggests an evolutionary relatedness of transplantation antigens, immunoglobulins and beta-2-microglobins (Tragardh et al., 1979). Both the class I MHC antigens (A, B, and C) and the class II antigens DR and DC1 are polymorphic 2-chain cell surface glycoproteins; they are recognized by different subsets of T cells and have different functions, tissue distributions, and structures. The light chain of class I antigens is beta-2-microglobulin (B2M; 109700), which is coded by chromosome 15. The heavy chain, coded by chromosome 6, has a molecular mass of 44,000 and is made up of 3 N-terminal extracellular domains of 90 amino acids each, a small hydrophobic membrane-spanning segment and a small hydrophilic intracellular C-terminal domain. The 2 N-terminal domains are polymorphic, bear the carbohydrate and have no sequence homology with immunoglobulin. The third domain, closest to the membrane, and the 11.6-kD B2M light chain are highly conserved and have strong sequence homology with immunoglobulin.;

Inheritance : Autosomal dominant (6p23-p21, probably 6p21.3);

Details

Origin ID

142800;

UMLS CUI

C1333899;

Automatic exact mappings (from CISMeF team)
- HLA Class I Histocompatibility Antigen, A-2 Alpha Chain [NCIt concept]
- HLA Complex [NCIt concept]
- HLA-A [LOINC component]
- HLA-A Gene [NCIt concept]
- HLA-A antigens [MeSH Descriptor]
- HLA-A antigens [MeSH concept]
- HLA-A locus [LOINC component]
- HLA-A wt Allele [NCIt concept]
- MHC Class II Protein [NCIt concept]
Currated CISMeF NLP mapping
- major histocompatibility complex, class I, A [ORDO Gene]
NCIt concept(s)
- HLA Class I Histocompatibility Antigen, A-0201 Alpha Chain [NCIt concept]
- HLA Class I Histocompatibility Antigen, A-0205 Alpha Chain [NCIt concept]
- HLA Class I Histocompatibility Antigen, A-0206 Alpha Chain [NCIt concept]
- HLA Class I Histocompatibility Antigen, A-0301 Alpha Chain [NCIt concept]
- HLA Class I Histocompatibility Antigen, A-1 Alpha Chain [NCIt concept]
- HLA Class I Histocompatibility Antigen, A-11 Alpha Chain [NCIt concept]
- HLA Class I Histocompatibility Antigen, A-2 Alpha Chain [NCIt concept]
- HLA Class I Histocompatibility Antigen, A-24 Alpha Chain [NCIt concept]
- HLA Class I Histocompatibility Antigen, A-2402 Alpha Chain [NCIt concept]
- HLA-A Gene [NCIt concept]
- HLA-A wt Allele [NCIt concept]
ORDO concept(s)
- major histocompatibility complex, class I, A [ORDO Gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
UMLS correspondences (same concept)
- HLA-A Gene [NCIt concept]
- major histocompatibility complex, class I, A [ORDO Gene]
- major histocompatibility complex, class I, A [HGNC gene]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients