MeSH definition : An ADAMTS protease that contains eight thrombospondin (TS) motifs. It cleaves VON
WILLEBRAND FACTOR to control vWF-mediated THROMBOSIS. Mutations in the ADAMTS13 gene
have been identified in familial cases of PURPURA, THROMBOTIC THROMBOCYTOPENIC and
defects in ADAMTS13 activity are associated with MYOCARDIAL INFARCTION; BRAIN ISCHEMIA;
PRE-ECLAMPSIA; and MALARIA.;
MeSH synonym : von Willebrand Factor-Cleaving Protease; von Willebrand Factor Cleaving Protease; ADAMTS13 Protease; vWF-Cleaving Protease; vWF Cleaving Protease; ADAMTS-13 Protein; ADAMTS 13 Protein; A Disintegrin and Metalloproteinase with Thrombospondin Motifs 13 Protein;
An ADAMTS protease that contains eight thrombospondin (TS) motifs. It cleaves VON
WILLEBRAND FACTOR to control vWF-mediated THROMBOSIS. Mutations in the ADAMTS13 gene
have been identified in familial cases of PURPURA, THROMBOTIC THROMBOCYTOPENIC and
defects in ADAMTS13 activity are associated with MYOCARDIAL INFARCTION; BRAIN ISCHEMIA;
PRE-ECLAMPSIA; and MALARIA.