ADAMTS13 Protein

Preferred Label : ADAMTS13 Protein;

MeSH definition : An ADAMTS protease that contains eight thrombospondin (TS) motifs. It cleaves VON WILLEBRAND FACTOR to control vWF-mediated THROMBOSIS. Mutations in the ADAMTS13 gene have been identified in familial cases of PURPURA, THROMBOTIC THROMBOCYTOPENIC and defects in ADAMTS13 activity are associated with MYOCARDIAL INFARCTION; BRAIN ISCHEMIA; PRE-ECLAMPSIA; and MALARIA.;

MeSH synonym : von Willebrand Factor-Cleaving Protease; von Willebrand Factor Cleaving Protease; ADAMTS13 Protease; vWF-Cleaving Protease; vWF Cleaving Protease; ADAMTS-13 Protein; ADAMTS 13 Protein; A Disintegrin and Metalloproteinase with Thrombospondin Motifs 13 Protein;

Registry Number MeSH : EC 3.4.24.87;

UNII : EC 3.4.24.87;

Details

Origin ID

D000071120;

UMLS CUI

C4255520;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- A Disintegrin and Metalloproteinase with Thrombospondin Motifs 13 [NCIt concept]
- A disintegrin-like and metalloprotease with thrombospondin type 1 motif, 13 [OMIM gene]
Record concept(s)
- ADAMTS13 Protein [MeSH concept]
Related MeSH Supplementary Concept(s)
- ADAMTS13 protein, human [MeSH Supplementary Concept]
- ADAMTS13 protein, mouse [MeSH Supplementary Concept]
- ADAMTS13 protein, rat [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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