Paraoxonase 1 - CISMeF

Preferred Label : Paraoxonase 1;

Symbol : PON1;

CISMeF acronym : ESA; PON; PON1;

Type : Gene and phenotype, combined;

Alternative titles and symbols : Paraoxonase, plasma; Esterase a; PON; ARYLESTERASE; ESA;

Included titles and symbols : Pon1 enzyme activity, variation in; Organophosphate poisoning, susceptibility to; Coronary artery disease, susceptibility to; Coronary artery spasm 2, susceptibility to;

Description : The paraoxonase (PON) gene family includes 3 genes, PON1, PON2 (602447), and PON3 (602720), aligned next to each other on chromosome 7. PON1 (EC 3.1.1.2) hydrolyzes the toxic oxon metabolites of several organophosphorous insecticides, including parathion, diazinon, and chlorpyrifos, as well as nerve agents, such as sarin and soman. PON1 also hydrolyzes aromatic esters, preferably those of acetic acid. In addition, PON1 hydrolyzes a variety of aromatic and aliphatic lactones, and it also catalyzes the reverse reaction, lactonization, of gamma- and delta-hydroxycarboxylic acids. Human PON1 is synthesized in liver and secreted into blood, where it is associated exclusively with high density lipoproteins (HDLs) and may protect against development of atherosclerosis (Draganov et al., 2005).;

Inheritance : Autosomal dominant (7q21-q22);

Prefixed ID : 168820;

Details

Origin ID

168820;

UMLS CUI

C1418754;

Automatic exact mappings (from CISMeF team)
- Aryldialkylphosphatase (substance) [SNOMED CT concept]
- Arylesterase [NCIt concept]
- Arylesterase (substance) [SNOMED CT concept]
- EPCAM wt Allele [NCIt concept]
- Entire pons (body structure) [SNOMED CT concept]
- Esterase [NCIt concept]
- Esterase (substance) [SNOMED CT concept]
- FLOT2 wt Allele [NCIt concept]
- PON1 Gene [NCIt concept]
- PON1 gene [LOINC component]
- PON1 wt Allele [NCIt concept]
- Paraoxonase-1 [MeSH concept]
- Pohnpeian Language [NCIt concept]
- Pons [FMA entity]
- Pons Varolii [NCIt concept]
- Pontine structure (body structure) [SNOMED CT concept]
- Serum Paraoxonase/Arylesterase 1 [NCIt concept]
- aryldialkylphosphatase [MeSH Descriptor]
- arylesterase [MeSH concept]
- arylesterase [MeSH Supplementary Concept]
- arylesterase [SNOMED Notion]
- atrial premature complexes [MeSH Descriptor]
- carboxylesterase [MeSH Descriptor]
- carboxylesterase activity [GO term]
- carboxylic ester hydrolase activity [GO term]
- epithelial cell adhesion molecule [ORDO Gene]
- esterases [MeSH concept]
- esterases [MeSH Descriptor]
- paraoxonase 1 [HGNC gene]
- pons [ICF N4 Element]
- pons [MeSH Descriptor]
- pons [MeSH concept]
- pons [Radlex concept]
- pons, nos [SNOMED Notion]
- preoccipital notch [UBERON concept]
Currated CISMeF NLP mapping
- paraoxonase 1 [ORDO Gene]
False automatic mappings
- Polish Lowland Sheepdog [NCIt concept]
HPO term(s)
- Abnormality of metabolism/homeostasis [HPO term]
- Autosomal dominant inheritance [HPO term]
NCIt concept(s)
- PON1 Gene [NCIt concept]
- PON1 wt Allele [NCIt concept]
- Serum Paraoxonase/Arylesterase 1 [NCIt concept]
ORDO concept(s)
- paraoxonase 1 [ORDO Gene]
See also inter- (CISMeF)
- Esterase [LOINC component]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
UMLS correspondences (same concept)
- PON1 Gene [NCIt concept]
- PON1 gene [LOINC component]
- paraoxonase 1 [ORDO Gene]
- paraoxonase 1 [HGNC gene]

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