tissue inhibitor of metalloproteinase-2

Preferred Label : tissue inhibitor of metalloproteinase-2;

MeSH definition : A member of the family of TISSUE INHIBITOR OF METALLOPROTEINASES. It is a 21-kDa nonglycosylated protein found in tissue fluid and is secreted as a complex with progelatinase A by human fibroblast and uncomplexed from alveolar macrophages. An overexpression of TIMP-2 has been shown to inhibit invasive and metastatic activity of tumor cells and decrease tumor growth in vivo.;

MeSH synonym : metalloproteinase-2 tissue inhibitor; timp-2; tissue inhibitor of metalloproteinase 2;

Registry Number MeSH : 127497-59-0;

Is substance : O;

Details

Origin ID

D019716;

UMLS CUI

C0145946;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Currated CISMeF NLP mapping
- Metalloproteinase Inhibitor 2 [NCIt concept]
Pharmacological action(s)
- matrix metalloproteinase inhibitors [MeSH Descriptor]
Record concept(s)
- tissue inhibitor of Metalloproteinase-2 [MeSH concept]
Related MeSH Supplementary Concept(s)
- 111In-DTPA-N-TIMP-2 [MeSH Supplementary Concept]
- TIMP2 protein, human [MeSH Supplementary Concept]
- Timp2 protein, mouse [MeSH Supplementary Concept]
- Timp2 protein, rat [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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