NCIt definition : A fusion protein (680 aa, 75 kDa) that is encoded by the RNF213/ALK fusion gene.
This protein contains 1172 N-terminal amino acids of E3 ubiquitin-protein ligase RNF213
fused to the cytoplasmic domain of the ALK tyrosine kinase receptor protein.;
NCIt note : The RNF213/ALK fusion protein is a constitutively dimerized and activated tyrosine
kinase.;