FIP1L1/PDGFRA Fusion Protein

Preferred Label : FIP1L1/PDGFRA Fusion Protein;

NCIt synonyms : Pre-mRNA 3'-End-Processing Factor FIP1/Alpha-Type Platelet-Derived Growth Factor Receptor Fusion Protein; FIP1L1-PDGFRA Fusion Protein; FIP1L1::PDGFRA Fusion Protein;

NCIt definition : A fusion protein (849, 95 kDa) encoded by the FIP1L1/PDGFRA fusion gene. This protein is comprised of the first 339 amino acids of pre-mRNA 3'-end-processing factor FIP1, fused to the C-terminal cytoplasmic domains of the alpha-type platelet-derived growth factor receptor protein, including the protein kinase domain.;

NCIt note : The FIP1L1/PDGFRA fusion protein is a constitutively activated tyrosine kinase because of a disruption of the juxtamembrane kinase regulatory domain of the alpha-type platelet-derived growth factor receptor protein. (OMIM);

Details

Origin ID

C99744;

UMLS CUI

C3274897;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- FIP1L1/PDGFRA Fusion Gene [NCIt concept]
- Fusion Gene [NCIt concept]
gene_product_plays_role_in_biological_process
- Tyrosine Phosphorylation [NCIt concept]
related_to_genetic_biomarker
- FIP1L1 Gene [NCIt concept]
- PDGFRA Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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