GOPC/ROS1 Fusion Protein

Preferred Label : GOPC/ROS1 Fusion Protein;

NCIt synonyms : GOPC-ROS1 Fusion Protein; GOPC::ROS1 Fusion Protein;

NCIt definition : A fusion protein (878, 109 kDa) encoded by the GOPC/ROS1 fusion gene. This protein is comprised of most of the Golgi-associated PDZ and coiled-coil motif-containing protein, including the coiled-coil and PDZ domains, fused to almost the entire C-terminal cytoplasmic domain of the proto-oncogene tyrosine-protein kinase ROS protein, including the protein kinase domain.;

NCIt note : The GOPC/ROS1 fusion protein is a constitutively dimerized and activated tyrosine kinase.;

PubMed : 12661006;

Details

Origin ID

C99720;

UMLS CUI

C3274877;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Fusion Gene [NCIt concept]
- GOPC/ROS1 Fusion Gene [NCIt concept]
gene_product_plays_role_in_biological_process
- Tyrosine Phosphorylation [NCIt concept]
related_to_genetic_biomarker
- GOPC Gene [NCIt concept]
- ROS1 Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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