TRIP11/PDGFRB Fusion Protein

Preferred Label : TRIP11/PDGFRB Fusion Protein;

NCIt synonyms : Thyroid Receptor-Interacting Protein 11/Beta-Type Platelet-Derived Growth Factor Receptor Fusion Protein; CEV14/PDGFRB Fusion Protein; TRIP11-PDGFRB Fusion Protein; CEV14-PDGFRB Fusion Protein; TRIP11::PDGFRB Fusion Protein;

NCIt definition : A fusion protein encoded by the TRIP11/PDGFRB fusion gene. This protein is comprised of the N-terminal leucine zipper domain of the thyroid receptor-interacting protein 11 fused to the C-terminal transmembrane and cytoplasmic domains of the beta-type platelet-derived growth factor receptor protein, including the tyrosine kinase domain.;

NCIt note : The TRIP11/PDGFRB fusion protein is a constitutively dimerized and activated tyrosine kinase.;

Details

Origin ID

C99687;

UMLS CUI

C3274864;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Fusion Gene [NCIt concept]
- TRIP11/PDGFRB Fusion Gene [NCIt concept]
gene_product_plays_role_in_biological_process
- Tyrosine Phosphorylation [NCIt concept]
related_to_genetic_biomarker
- PDGFRB Gene [NCIt concept]
- TRIP11 Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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