BCR/FGFR1 Fusion Protein

Preferred Label : BCR/FGFR1 Fusion Protein;

NCIt synonyms : Breakpoint Cluster Region Protein/Basic Fibroblast Growth Factor Receptor 1 Fusion Protein; BCR/FGFR Fusion Protein; BCR-FGFR1 Fusion Protein; BCR::FGFR1 Fusion Protein; Breakpoint Cluster Region Protein::Basic Fibroblast Growth Factor Receptor 1 Fusion Protein;

NCIt definition : A fusion protein encoded by the BCR/FGFR1 fusion gene. This protein is comprised of the coiled-coil domain and Grb2 binding site of breakpoint cluster region protein followed by the tyrosine kinase domains of the basic fibroblast growth factor receptor 1.;

NCIt note : The BCR/FGFR1 fusion protein is a constitutively dimerized and activated tyrosine kinase.;

Details

Origin ID

C99312;

UMLS CUI

C3274674;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- BCR/FGFR1 Fusion Gene [NCIt concept]
- Fusion Gene [NCIt concept]
gene_product_plays_role_in_biological_process
- Tyrosine Phosphorylation [NCIt concept]
related_to_genetic_biomarker
- BCR Gene [NCIt concept]
- FGFR1 Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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