Preferred Label : Icatibant Acetate;
NCIt synonyms : Hoechst 140; L-Arginine, D-arginyl-L-arginyl-L-prolyl-trans-4-hydroxy-L-prolylglycyl-3-(2-thienyl)-L-alanyl-L-seryl-D-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-L-(2alpha,3abeta,7abeta)-octahydro-1H-indole-2-carbonyl-,
Acetate;
NCIt definition : The acetate salt form of icatibant, an antagonist of the human bradykinin B2 receptor
(B2R), that can be used for the treatment of hereditary angioedema (HAE). Upon administration,
icatibant targets and binds to B2R, thereby preventing bradykinin from binding to
the B2R. This may prevent bradykinin/B2R-mediated vasodilation, the resulting increase
in vascular permeability, and the swelling, inflammation, and pain associated with
HAE. This may also prevent or improve pulmonary edema not associated with HAE and
improve the associated decrease in blood oxygen levels.;
UNII : 325O8467XK;
InChIKey : HKMZRZUEADSZDQ-DZJWSCHMSA-N;
CAS number : 138614-30-9;
Drug name : Firazyr;
Molecule name : HOE140; JE049;
Chemical formula : C59H89N19O13S.C2H4O2;
Origin ID : C98884;
UMLS CUI : C0286722;
CISMeF manual mappings
Currated CISMeF NLP mapping
Semantic type(s)
UMLS correspondences (same concept)
Validated automatic mappings to NTBT
concept_is_in_subset
has_free_acid_or_base_form
is_salt_form_of