Preferred Label : Icatibant;
NCIt synonyms : L-Arginine, D-arginyl-L-arginyl-L-prolyl-trans-4-hydroxy-L-prolylglycyl-3-(2-thienyl)-L-alanyl-L-seryl-D-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-L-(2alpha,3abeta,7abeta)-octahydro-1H-indole-2-carbonyl-;
NCIt definition : An antagonist of the human bradykinin B2 receptor (B2R), that can be used for the
treatment of hereditary angioedema (HAE). Upon administration, icatibant targets and
binds to B2R, thereby preventing bradykinin from binding to the B2R. This may prevent
bradykinin/B2R-mediated vasodilation, the resulting increase in vascular permeability,
and the swelling, inflammation, and pain associated with HAE. This may also prevent
or improve pulmonary edema not associated with HAE and improve the associated decrease
in blood oxygen levels.;
UNII : 7PG89G35Q7;
InChIKey : QURWXBZNHXJZBE-SKXRKSCCSA-N;
CAS number : 130308-48-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 130308-48-4
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G-SRS /a ;
Chemical formula : C59H89N19O13S;
Origin ID : C98883;
UMLS CUI : C0246269;
Automatic exact mappings (from CISMeF team)
- CISMeF manual mappings
- Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- has_salt_form
- is_free_acid_or_base_form_of
