Klotho - CISMeF

Preferred Label : Klotho;

NCIt synonyms : EC 3.2.1.31; KL;

NCIt definition : Klotho (1012 aa, 116 kDa) is encoded by the human KL gene. This protein is involved in signal transduction.;

NCIt note : Klotho may have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. (UniProt);

Details

Origin ID

C98116;

UMLS CUI

C1144173;

OMIM relation
- Klotho [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- KL protein, human [MeSH concept]
- KL protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- KL Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Pentose and Glucuronate Interconversions Pathway [NCIt concept]
- Starch and Sucrose Metabolism Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Aging [NCIt concept]
- Carbohydrate Metabolic Process [NCIt concept]
- Hydrolysis [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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