Preferred Label : Rolapitant;
NCIt synonyms : 1,7-diazaspiro(4.5)decan-2-one, 8-(((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)methyl)-8-phenyl-,
(5S,8S)-;
NCIt definition : An orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor)
antagonist, with potential antiemetic activity. Upon oral administration, rolapitant
competitively binds to and blocks the activity of the NK1-receptor in the central
nervous system, thereby inhibiting the binding of the endogenous ligand, substance
P (SP). This may prevent both SP-induced emesis and chemotherapy-induced nausea and
vomiting (CINV). The interaction of SP with the NK1-receptor plays a key role in the
induction of nausea and vomiting caused by emetogenic cancer chemotherapy. Compared
to other NK1-receptor antagonists, rolapitant has both a more rapid onset of action
and a much longer half-life.;
UNII : NLE429IZUC;
InChIKey : FIVSJYGQAIEMOC-ZGNKEGEESA-N;
CAS number : 552292-08-7;
Chemical formula : C25H26F6N2O2;
Codes from synonyms : 450;
Origin ID : C97952;
UMLS CUI : C3273719;
CISMeF manual mappings
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- has_salt_form
- is_free_acid_or_base_form_of
