Preferred Label : Rolapitant Hydrochloride;
NCIt synonyms : 1,7-Diazaspiro(4.5)decan-2-one, 8-(((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)methyl)-8-phenyl-,
Monohydrochloride, Monohydrate, (5S,8S)-; Rolapitant Monohydrochloride Monohydrate; Rolapitant HCl; Rolapitant Hydrochloride Monohydrate;
NCIt definition : The hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting,
selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic
activity. Upon oral administration, rolapitant competitively binds to and blocks the
activity of the NK1-receptor in the central nervous system, thereby inhibiting the
binding of the endogenous ligand, substance P (SP). This may prevent both SP-induced
emesis and chemotherapy-induced nausea and vomiting (CINV). The interaction of SP
with the NK1-receptor plays a key role in the induction of nausea and vomiting caused
by emetogenic cancer chemotherapy. Compared to other NK1-receptor antagonists, rolapitant
has both a more rapid onset of action and a much longer half-life.;
UNII : 57O5S1QSAQ;
InChIKey : GZQWMYVDLCUBQX-WVZIYJGPSA-N;
CAS number : 914462-92-3;
Drug name : Varubi; Varuby;
Molecule name : SCH-619734; SCH 619734;
Chemical formula : C25H26F6N2O2.ClH.H2O;
Origin ID : C97955;
UMLS CUI : C3273721;
Currated CISMeF NLP mapping
- Manual NTBT mappings (CISMeF)
- Semantic type(s)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
