Namilumab - CISMeF

Preferred Label : Namilumab;

NCIt synonyms : Immunoglobulin G1, Anti-(Human Colony-Stimulating Factor 2) (Human Monoclonal MT203 Heavy Chain), Disulfide With Human Monoclonal MT203 Kappa-Chain, Dimer;

NCIt definition : A human IgG1, monoclonal antibody targeting GM-CSF, with immunomodulating activity. Namilumab binds to and neutralizes GM-CSF, by preventing GM-CSF from binding to its cell surface receptor, GM-CSFR. This leads to an inhibition of GM-CSF-mediated signaling and ultimately prevents inflammation. GM-CSF, a pro-inflammatory cytokine, stimulates the production of granulocytes and monocytes; it plays a key role in the activation of the innate immune system and in various autoimmune and inflammatory diseases.;

UNII : MED485W763;

CAS number : 1206681-39-1;

Molecule name : MT203;

Details

Origin ID

C97943;

UMLS CUI

C3273714;

Automatic exact mappings (from CISMeF team)
- namilumab [MeSH concept]
Currated CISMeF NLP mapping
- namilumab [MeSH Supplementary Concept]
See also inter- (CISMeF)
- granulocyte-macrophage colony-stimulating factor [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- namilumab [MeSH Supplementary Concept]
chemical_or_drug_affects_gene_product
- Granulocyte-Macrophage Colony-Stimulating Factor [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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