Proprotein Convertase Subtilisin/Kexin Type 7

Preferred Label : Proprotein Convertase Subtilisin/Kexin Type 7;

NCIt synonyms : PCSK7; Proprotein Convertase 8; Proprotein Convertase 7; hPC8; EC 3.4.21.-; PC7; PC8; Subtilisin/Kexin-Like Protease PC7; Lymphoma Proprotein Convertase; Prohormone Convertase 7;

NCIt definition : Proprotein convertase subtilisin/kexin type 7 (785 aa, 86 kDa) is encoded by the human PCSK7 gene. This protein is involved in the proteolytic processing of immature proteins.;

NCIt note : Proprotein convertase subtilisin/kexin type 7 releases mature proteins from their proproteins through cleavage of Arg-Xaa-Xaa-Xaa-Yaa-Arg-/-Zaa bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. (UniProt);

Details

Origin ID

C97658;

UMLS CUI

C1438155;

Automatic exact mappings (from CISMeF team)
- PC7 (body structure) [SNOMED CT concept]
- PC8 (body structure) [SNOMED CT concept]
- Pontocerebellar hypoplasia type 8 [ORDO Disease]
- Proprotein convertase, subtilisin/kexin-type, 7 [OMIM gene]
- Prostate cancer, hereditary, 8 [OMIM Phenotype]
- proprotein convertase subtilisin/kexin type 7 [HGNC gene]
OMIM relation
- Proprotein convertase, subtilisin/kexin-type, 7 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- PCSK7 protein, human [MeSH Supplementary Concept]
- PCSK7 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- PCSK7 Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Membrane of the Golgi Apparatus [NCIt concept]
gene_product_has_biochemical_function
- Endopeptidase [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]
- Protein Cleavage [NCIt concept]
- Proteolysis [NCIt concept]
- Proteolytic Processing [NCIt concept]

Keyword's position in hierarchy(ies) :

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