Rho GTPase-Activating Protein 35

Preferred Label : Rho GTPase-Activating Protein 35;

NCIt synonyms : p190-A; GRF1; Glucocorticoid Receptor Repression Factor 1; ARHGAP35; Rho GAP p190A; Glucocorticoid Receptor DNA-Binding Factor 1; Rho GTPase Activating Protein 35;

NCIt definition : Rho GTPase-activating protein 35 (1499 aa, 171 kDa) is encoded by the human ARHGAP35 gene. This protein is involved in both the activation of Rac GAP activity and the inhibition of glucocorticoid receptor expression.;

NCIt note : Rho GTPase-activating protein 35 may regulate transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'. (UniProt);

Details

Origin ID

C97270;

UMLS CUI

C0119391;

OMIM relation
- Rho gtpase-activating protein 35 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- ARHGAP35 protein, human [MeSH Supplementary Concept]
- ARHGAP35 protein, human [MeSH concept]
gene_encodes_gene_product
- ARHGAP35 Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
gene_product_has_biochemical_function
- Sequence-Specific DNA Binding Protein [NCIt concept]
- Transcription Repressor/Corepressor [NCIt concept]
gene_product_is_element_in_pathway
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
- Ephrin A2 Forward Signaling Pathway [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
- Leukocyte Transendothelial Migration Pathway [NCIt concept]
- PDGFR-beta Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Transcriptional Repression [NCIt concept]

Keyword's position in hierarchy(ies) :

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