Preferred Label : Spebrutinib;
NCIt synonyms : Bruton's Tyrosine Kinase Inhibitor CC-292; 2-Propenamide, N-(3-((5-fluoro-2-((4-(2-methoxyethoxy)phenyl)amino)-4-pyrimidinyl)amino)phenyl)-;
NCIt definition : An orally bioavailable, selective inhibitor of Bruton's agammaglobulinemia tyrosine
kinase (BTK), with potential antineoplastic activity. Upon administration, spebrutinib
targets and covalently binds to BTK, thereby preventing its activity. By irreversibly
inhibiting BTK, administration of this agent may lead to an inhibition of B cell receptor
(BCR) signaling and may inhibit cell proliferation of B-cell malignancies. BTK, a
cytoplasmic tyrosine kinase and member of the Tec family of kinases, plays an important
role in B lymphocyte development, activation, signaling, proliferation and survival.;
UNII : DRU6NG543J;
InChIKey : KXBDTLQSDKGAEB-UHFFFAOYSA-N;
CAS number : 1202757-89-8;
Molecule name : AVL-292; CC-292; AVL 292; CC 292;
Codes from synonyms : 471;
Origin ID : C97037;
UMLS CUI : C4287807;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_salt_form
- has_target
- is_free_acid_or_base_form_of
