Preferred Label : Spebrutinib Besylate;
NCIt synonyms : CC-292 Besylate; N-(3-((5-fluoro-2-((4-(2-methoxyethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)prop-2-enamide
Benzenesulfonate; 2-Propenamide, N-(3-((5-fluoro-2-((4-(2-methoxyethoxy)phenyl)amino)-4-pyrimidinyl)amino)phenyl)-,
Benzenesulfonate (1:1);
NCIt definition : The besylate salt form of spebrutinib, an orally bioavailable, selective inhibitor
of Bruton's agammaglobulinemia tyrosine kinase (BTK), with potential antineoplastic
activity. Upon administration, spebrutinib targets and covalently binds to BTK, thereby
preventing its activity. By irreversibly inhibiting BTK, administration of this agent
may lead to an inhibition of B cell receptor (BCR) signaling and may inhibit cell
proliferation of B-cell malignancies. BTK, a cytoplasmic tyrosine kinase and member
of the Tec family of kinases, plays an important role in B lymphocyte development,
activation, signaling, proliferation and survival.;
UNII : RC3ET192UJ;
InChIKey : ABSXPNGWJFAPRT-UHFFFAOYSA-N;
CAS number : 1360053-81-1;
NCI Metathesaurus CUI : CL539505;
Origin ID : C141425;
UMLS CUI : C4683807;
Semantic type(s)
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_salt_form_of
