NCIt definition : A monoclonal antibody directed against the Wnt signaling pathway with potential antineoplastic
activity. Upon administration, vantictumab binds to certain receptors in the Wnt signaling
pathway thereby preventing the activation of the Wnt signaling pathway. This may result
in an inhibition of cancer stem cell (CSC) activity and a subsequent inhibition of
cancer cell proliferation. The Wnt signaling pathway is dysregulated in many cancer
cell types and appears to play a major role in CSC regulation and activity; CSC are
tumor initiating cells that are able to self-renew and are responsible for tumor growth
and resistance.;
UNII : 88WBI2D80S;
CAS number : 1345009-45-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1345009-45-1
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Semantic type(s)