SarCNU - CISMeF

Preferred Label : SarCNU;

NCIt related terms : 2-CHLOROETHYL-3-SARCOSINAMIDE-1-NITROSOUREA; sarcosinamide nitrosourea;

NCIt definition : An alkylating chloroethylnitrosourea with antineoplastic activity. Selectively accumulating in some tumor cells, SarCNU forms covalent linkages with nucleophilic centers in DNA, causing depurination, base pair miscoding, strand scission, and DNA-DNA cross-linking, which may result in cytotoxicity. (NCI04);

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. It is a type of alkylating agent.;

UNII : BHB013S3MO;

CAS number : 92891-93-5;

NSC code : 364432;

Codes from synonyms : CDR0000288845; CDR0000046182;

Details

Origin ID

C963;

UMLS CUI

C0045644;

Currated CISMeF NLP mapping
- 2-((((2-chloroethyl)nitrosoamino)carbonyl)amino)propanamide [MeSH Supplementary Concept]
- 2-((((2-chloroethyl)nitrosoamino)carbonyl)amino)propanamide [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- 2-((((2-chloroethyl)nitrosoamino)carbonyl)amino)propanamide [MeSH concept]
- 2-((((2-chloroethyl)nitrosoamino)carbonyl)amino)propanamide [MeSH Supplementary Concept]
chemical_or_drug_has_mechanism_of_action
- DNA Alkylation [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Base Pair Miscoding [NCIt concept]
- DNA Crosslinking [NCIt concept]
- DNA Replication Inhibition [NCIt concept]
- DNA Strand Break [NCIt concept]
- Depurination [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- DNA [NCIt concept]

Keyword's position in hierarchy(ies) :

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