Depurination - CISMeF

Preferred Label : Depurination;

NCIt definition : Depurination involves cleavage of the N-glycosidic link between a purine base and the remaining deoxyribose portion of the effected nucleotide in DNA, leading to loss of the purine base while leaving the DNA backbone intact. Depurination must be enzymically repaired to ensure genetic stability; transversion mutations result from purine loss.;

Details

Origin ID

C41574;

UMLS CUI

C1158480;

Automatic exact mappings (from CISMeF team)
- Dependency, Psychological [MeSH Descriptor]
- behavior, addictive [MeSH Descriptor]
- depurination [GO term]
Semantic type(s)
- Genetic Function [UMLS semantic type]
UMLS correspondences (same concept)
- depurination [GO term]
biological_process_involves_gene_product
- DNA-3-Methyladenine Glycosylase [NCIt concept]
biological_process_is_part_of_process
- Biochemical Process [NCIt concept]
is_physiologic_effect_of_chemical_or_drug
- SarCNU [NCIt concept]
process_involves_gene
- MPG Gene [NCIt concept]
- MPG wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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