High Grade Pancreatic Intraepithelial Neoplasia

Preferred Label : High Grade Pancreatic Intraepithelial Neoplasia;

NCIt synonyms : Grade III Pancreatic Intraepithelial Neoplasia; Grade 3 Pancreatic Intraepithelial Neoplasia; High-Grade PanIN; High-Grade Pancreatic Intraepithelial Neoplasia; High Grade PanIN; Pancreatic Intraepithelial Neoplasia-3;

NCIt related terms : PanIN-3;

NCIt definition : A pancreatic epithelial neoplasia characterized by the presence of papillary and rarely flat architectural patterns with formation of cribriform patterns and luminal necrosis. Severe dysplasia is present.;

Neoplastic status : Uncertain Malignant Potential;

Details

Origin ID

C95432;

UMLS CUI

C2987145;

Disease excludes abnormal cell
- Dysplastic Squamous Cell [NCIt concept]
- Neoplastic Smooth Muscle Cell [NCIt concept]
- Neoplastic Squamous Cell [NCIt concept]
Has associated anatomic sites
- Digestive System [NCIt concept]
- Pancreas [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
concept_is_in_subset
- CPTAC Baseline Medical Forms Terminology [NCIt concept]
- CPTAC Pancreatic Baseline Form [NCIt concept]
- CPTAC Terminology [NCIt concept]
disease_excludes_finding
- Invasive Lesion [NCIt concept]
- Mixed Neoplastic Glandular and Squamous Cell Population [NCIt concept]
disease_has_abnormal_cell
- Dysplastic Epithelial Cell [NCIt concept]
- Dysplastic Glandular Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Epithelial Cell [NCIt concept]
- Neoplastic Glandular Cell [NCIt concept]
disease_has_finding
- Borderline Lesion [NCIt concept]
- Dysplasia [NCIt concept]
- Epithelial Component Present [NCIt concept]
disease_has_grade
- Grade 3 [NCIt concept]
- High Grade [NCIt concept]
disease_has_normal_cell_origin
- Epithelial Cell [NCIt concept]
- Glandular Cell [NCIt concept]
disease_has_normal_tissue_origin
- Epithelial Tissue [NCIt concept]
- Epithelium [NCIt concept]
- Glandular Epithelium [NCIt concept]
disease_has_primary_anatomic_site
- Digestive System [NCIt concept]
- Exocrine Pancreas [NCIt concept]
- Pancreas [NCIt concept]
- Pancreatic Duct [NCIt concept]
disease_mapped_to_gene
- BRCA2 Gene [NCIt concept]
- KRAS Gene [NCIt concept]
- SMAD4 Gene [NCIt concept]
- TP53 Gene [NCIt concept]
disease_may_have_molecular_abnormality
- Inactivating BRCA2 Gene Mutation [NCIt concept]
- KRAS Gene Mutation [NCIt concept]
- SMAD4 Gene Inactivation [NCIt concept]
- TP53 Gene Inactivation [NCIt concept]
pathogenesis_of_disease_involves_gene
- SMAD4 Gene [NCIt concept]
- SMAD4 wt Allele [NCIt concept]
- TP53 Gene [NCIt concept]
- TP53 wt Allele [NCIt concept]
- TP53*1 Allele [NCIt concept]

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