Pegaptanib Sodium

Preferred Label : Pegaptanib Sodium;

NCIt definition : The sodium salt form of pegaptanib, a 28-mer RNA aptamer covalently linked to two branched 20-kD polyethylene glycol (PEG) chains, with anti-angiogenic activity. Pegaptanib binds and blocks the activity of the extracellular vascular endothelial growth factor, specifically the 165-amino acid isoform (VEGF165). This prevents VEGF165 from binding to VEGF receptors, thereby blocking angiogenesis as well as preventing VEGF165-induced increases in vessel permeability. VEGF165 is preferentially involved in pathological ocular neovascularisation.;

UNII : 3HP012Q0FH;

CAS number : 222716-86-1;

Molecule name : EYE001; NX1838;

Chemical formula : C15H28N3O6(C2H4O)n(C2H4O)n.28Na;

Details

Origin ID

C95230;

UMLS CUI

C1576729;

Automatic exact mappings (from CISMeF team)
- pegaptanib [MeSH Supplementary Concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Pegaptanib sodium (substance) [SNOMED CT concept]
- pegaptanib sodium [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_free_acid_or_base_form
- Pegaptanib [NCIt concept]
is_salt_form_of
- Pegaptanib [NCIt concept]

Keyword's position in hierarchy(ies) :

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