Pegaptanib - CISMeF

Preferred Label : Pegaptanib;

NCIt definition : A 28-mer RNA aptamer covalently linked to two branched 20-kD polyethylene glycol (PEG) chains, with anti-angiogenic activity. Pegaptanib binds and blocks the activity of the extracellular vascular endothelial growth factor, specifically the 165-amino acid isoform (VEGF165). This prevents VEGF165 from binding to VEGF receptors, thereby blocking angiogenesis as well as preventing VEGF165-induced increases in vessel permeability. VEGF165 is preferentially involved in pathological ocular neovascularisation.;

UNII : 2H1PA8H1EN;

Details

Origin ID

C90657;

UMLS CUI

C1531015;

Currated CISMeF NLP mapping
- Pegaptanib [ICD-11 Extension code]
- Pegaptanib [SMS substance]
- Pegaptanib (substance) [SNOMED CT concept]
- Product containing pegaptanib (medicinal product) [SNOMED CT concept]
- pegaptanib [MeSH concept]
- pegaptanib [MeSH Supplementary Concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Pegaptanib (substance) [SNOMED CT concept]
- Product containing pegaptanib (medicinal product) [SNOMED CT concept]
- pegaptanib [ATC Code]
- pegaptanib [MeSH concept]
- pegaptanib [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- pegaptanib [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_salt_form
- Pegaptanib Sodium [NCIt concept]
is_free_acid_or_base_form_of
- Pegaptanib Sodium [NCIt concept]

Keyword's position in hierarchy(ies) :

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