Preferred Label : Phase II Detoxification;
Alternative definition : NCI-GLOSS: A process in which the liver uses one of two major enzyme pathways to change
a toxic substance, such as an anticancer drug, into a less toxic substance that is
easier for the body to excrete. In phase II detoxification, liver cells add a substance
(such as cysteine, glycine, or a sulfur molecule) to a toxic chemical or drug, to
make it less harmful.;
NCIt note : Phase II detoxification pathways leverage transferases to conjugate large water-soluble
molecule with toxins, usually at a reactive site formed during Phase I detoxification.
Following conjugation, the body is able to eliminate the transformed toxins in the
urine or the feces. (see Peace-Brewer, AL. DetoxiGenomic Profile, Physicians Copy.
Genova Diagnostics. GDX-4-179. GDG02 RMS 1427 Rev 1);
Codes from synonyms : CDR0000390310;
Origin ID : C93206;
UMLS CUI : C1563755;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- biological_process_is_part_of_process
