Phase I Detoxification

Preferred Label : Phase I Detoxification;

Alternative definition : NCI-GLOSS: A process in which the liver uses one of two major enzyme pathways to change a toxic substance, such as an anticancer drug, into a less toxic substance that is easier for the body to excrete.;

NCIt note : Phase I detoxification pathways involve the oxidation of toxins, drugs or steroid hormones by cytochrome P-450 system enzymes. (see Peace-Brewer, AL. DetoxiGenomic Profile, Physicians Copy. Genova Diagnostics. GDX-4-179. GDG02 RMS 1427 Rev 1);

Codes from synonyms : CDR0000390309;

Details

Origin ID

C93205;

UMLS CUI

C1563754;

Currated CISMeF NLP mapping
- metabolic detoxication, phase I [MeSH concept]
- metabolic detoxication, phase i [MeSH Descriptor]
Semantic type(s)
- Organism Function [UMLS semantic type]
UMLS correspondences (same concept)
- metabolic detoxication, phase I [MeSH concept]
- metabolic detoxication, phase i [MeSH Descriptor]
biological_process_is_part_of_process
- Host Defense Mechanism [NCIt concept]
- Resistance Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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