" /> metabolic detoxication, phase i - CISMeF





Preferred Label : metabolic detoxication, phase i;

MeSH definition : Functionalization of exogenous substances to prepare them for conjugation in PHASE II DETOXIFICATION. Phase I enzymes include CYTOCHROME P450 enzymes and some OXIDOREDUCTASES. Excess induction of phase I over phase II detoxification leads to higher levels of FREE RADICALS that can induce CANCER and other cell damage. Induction or antagonism of phase I detoxication is the basis of a number of DRUG INTERACTIONS.;

MeSH synonym : detoxication, oxidative metabolic; detoxications, oxidative metabolic; detoxification, phase i; detoxifications, phase i; metabolic detoxication, oxidative; metabolic detoxications, oxidative; metabolic detoxification, phase i; oxidative metabolic detoxication; oxidative metabolic detoxications; phase i detoxification;

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Functionalization of exogenous substances to prepare them for conjugation in PHASE II DETOXIFICATION. Phase I enzymes include CYTOCHROME P450 enzymes and some OXIDOREDUCTASES. Excess induction of phase I over phase II detoxification leads to higher levels of FREE RADICALS that can induce CANCER and other cell damage. Induction or antagonism of phase I detoxication is the basis of a number of DRUG INTERACTIONS.

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02/06/2024


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